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Ivermectin Induces Oxidative Stress and DNA Damage in Breast Cancer Cells

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dc.contributor.authorGüler E. M.
dc.contributor.authorGünaydın Akyıldız A.
dc.contributor.institutionauthorGÜNAYDIN AKYILDIZ, AYŞENUR
dc.date.accessioned2023-02-01T21:30:24Z
dc.date.available2023-02-01T21:30:24Z
dc.date.issued2023-01-01
dc.description.abstractObjective: Breast cancer (BC) remains to be one of the most diagnosed cancer types among women around the world. Drug repurposing is suggested to be a convenient alternative for drug development in cancer treatment. Ivermectin, the antiparasitic agent produced by the bacterium Streptomyces avermitilis, is currently being examined thoroughly in oncology and has begun to be seen as a potential drug candidate for BC therapy. However, studies are limited, and the exact anti-tumorigenic mechanism is not yet clarified in breast cancer. Methods: For elucidating the molecular mechanisms of Ivermectin’s potential anticancer effects, we have examined its in vitro effects on BC cells in terms of cell viability, intracellular ROS levels, glutathione levels, mitochondrial membrane potential, apoptosis, and DNA damage. Results: Ivermectin induces apoptosis via oxidative stress and DNA damage in BC cells. Conclusion: The in vitro mechanistic studies of promising anticancer agents for repurposing are essential guides for drug developers. For this purpose, ivermectin should be further studied as a drug candidate for its potential in the treatment of breast cancer.
dc.identifier.citationGüler E. M., Günaydın Akyıldız A., "Ivermectin Induces Oxidative Stress and DNA Damage in Breast Cancer Cells", BEZMIALEM SCIENCE, sa.11, ss.15-22, 2023
dc.identifier.doi10.14235/bas.galenos.2022.54254
dc.identifier.endpage22
dc.identifier.issn2148-2373
dc.identifier.issue11
dc.identifier.startpage15
dc.identifier.urihttps://www.bezmialemscience.org/archives/archive-detail/article-preview/vermectin-nduces-oxidative-stress-and-dna-damage-i/58421
dc.identifier.urihttps://hdl.handle.net/20.500.12645/35150
dc.identifier.wosWOS:000928065300004
dc.relation.ispartofBEZMIALEM SCIENCE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIvermectin
dc.subjectbreast cancer
dc.subjectdrug repurposing
dc.subjectDNA damage
dc.subjectoxidative stress
dc.titleIvermectin Induces Oxidative Stress and DNA Damage in Breast Cancer Cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id3ae0162f-d11a-43c4-82fe-5f3560b1b149
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
relation.isAuthorOfPublication98a70592-2158-4e37-b8d7-80d3bd64c98c
relation.isAuthorOfPublication.latestForDiscovery98a70592-2158-4e37-b8d7-80d3bd64c98c
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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