Publication:
Intraarticular Hyaluronic Acid Injection after Microfracture Technique for the Management of Full-Thickness Cartilage Defects Does Not Improve the Quality of Repair Tissue.

dc.contributor.authorGunes, Taner
dc.contributor.authorBostan, Bora
dc.contributor.authorErdem, Mehmet
dc.contributor.authorKoseoglu, Resid Dogan
dc.contributor.authorAsci, Murat
dc.contributor.authorSen, Cengiz
dc.date.accessioned2023-05-16T17:03:31Z
dc.date.available2023-05-16T17:03:31Z
dc.date.issued2011-12-31T22:00:00Z
dc.description.abstractTissue repair that occurs after microfracture does not include hyaline-like cartilage. Therefore, other treatment modalities must be combined with microfracture to improve repair tissue quality. In this study, we combined exogenous hyaluronic acid with microfracture.
dc.description.abstractThirty mature New Zealand rabbits were randomly divided into 3 groups as control, microfracture (MF), and microfracture and hyaluronic acid (MFHA). Four-millimetre full-thickness cartilage defects were created in the medial femoral condyle of each rabbit. Microfracture was performed on defects in the MF and MFHA groups. At 1 week following surgery, 1 mL of saline was injected into the knees of the control and MF groups, whereas 1 mL (15 mg/mL) hyaluronic acid was injected into the knees of the MFHA group 3 times weekly. At 6 months postsurgery, defects were evaluated according to the ICRS (International Cartilage Repair Society) and Wakitani scales.
dc.description.abstractAccording to the ICRS and Wakitani scales, the quality of repair tissue was improved in MF and MFHA groups as compared the control group (P = 0.001 and 0.001, respectively). No significant difference was observed between the MF and MFHA groups (P = 0.342).
dc.description.abstractAccording to the model in this study, no beneficial effect was obtained when HA injection was combined with microfracture in the treatment of full-thickness cartilage defects.
dc.identifier.pubmed26069616
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38270
dc.language.isoen
dc.subjectarticular cartilage
dc.subjecthyaluronic acid
dc.subjectintraarticular delivery
dc.subjectmicrofracture
dc.subjectrepair issues
dc.titleIntraarticular Hyaluronic Acid Injection after Microfracture Technique for the Management of Full-Thickness Cartilage Defects Does Not Improve the Quality of Repair Tissue.
dspace.entity.typePublication
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