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Circulating levels of cytokines are increased in restless legs syndrome.

dc.contributor.authorUslu, FI
dc.contributor.authorKoçyiğit, A
dc.contributor.authorDemir, E
dc.contributor.authorGüler, Eray Metin
dc.contributor.institutionauthorUSLU, FERDA
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2020-10-26T17:22:46Z
dc.date.available2020-10-26T17:22:46Z
dc.date.issued2020-10-21T00:00:00Z
dc.description.abstractBackground: Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic dysregulation but inflammatory processes might also have a role in the pathogenesis. In this study, we compared the circulating levels of hsCRP, IL-1β, IL-6, and TNF-α in patients with primary restless legs syndrome [RLS] and healthy control subjects. Methods: We prospectively included 29 patients with primary RLS and 65 healthy controls [HC], all age-sex matched. The diagnosis of RLS was established using international guidelines. IRLSSG Severity Scale was used to evaluate the severity of RLS. Plasma levels of hsCRP, IL-1β, IL-6, and TNF-α were measured in all participants. Results: The mean age of patients was 37.8 ± 11.3 and 52% of RLS group were women. Serum IL-1β, IL-6, and TNF-α levels of the patient group were statistically significantly higher compared to HC [p < 0.001 for all variables]. Plasma levels of hsCRP did not differ between groups. There were 8 patients with mild RLS [28%], 13 patients with moderate RLS [45%], and 8 patients with severe RLS [28%]. Only IL-6 values were significantly different between the groups. In the severe group, the value of IL-6 was significantly higher than in the other groups [p: 0.03]. Conclusion: These results showing higher circulating levels of inflammatory cytokines in patients with RLS support the notion that inflammation may be involved in the pathogenesis of primary RLS. However, it is necessary to perform further studies to determine if this finding is a cause or an effect.en
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier.citationUslu F., Demir E., Güler E. M. , Koçyiğit A., -Circulating levels of cytokines are increased in restless legs syndrome.-, Sleep & breathing = Schlaf & Atmung, 2020
dc.identifier.doi10.1007/s11325-020-02218-7
dc.identifier.pubmed33083922
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25025
dc.identifier.urihttps://link.springer.com/article/10.1007/s11325-020-02218-7
dc.subjectInterleukin-1βen
dc.subjectInterleukin-6
dc.subjectRestless legs syndromeen
dc.subjectTNF-αen
dc.subjectNeurologyen
dc.titleCirculating levels of cytokines are increased in restless legs syndrome.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id382c64a5-940d-4e9d-bbd3-023725030eb7
local.publication.isinternational1
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relation.isAuthorOfPublication68927a51-77a5-4d08-8370-23b470160061
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
relation.isAuthorOfPublication.latestForDiscovery75babbd2-f46b-4121-aa00-54d883a6f907
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