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The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats

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dc.contributor.authorBozkurt, SÜLEYMAN
dc.contributor.authorGUNER, Ali
dc.contributor.authorKadioglu, HÜSEYİN
dc.contributor.authorKECE, Can
dc.contributor.authorREIS, Erhan
dc.contributor.authorCOSKUN, HALİL
dc.contributor.institutionauthorBOZKURT, SÜLEYMAN
dc.contributor.institutionauthorKADIOĞLU, HÜSEYİN
dc.contributor.institutionauthorCOŞKUN, HALIL
dc.date.accessioned2020-10-29T21:52:33Z
dc.date.available2020-10-29T21:52:33Z
dc.date.issued2013-12-01T00:00:00Z
dc.description.abstractBackground/aims: To investigate the effects of different mechanisms on the development of pancreatitis after endoscopic retrograde cholangiopancreatography. Material and Methods: 40 male rats were randomly divided into four groups. After laparotomy, in Group 1, only duodenum was reached by a 24G cannula without performing any other procedure. In Groups 2, 3, and 4, biliopancreatic duct was cannulated transduodenally. Group 2 received no additional intervention after the cannulation. Group 3 received saline, whereas Group 4 received contrast agent into the duct. After a period of 24 hours, all rats were sacrificed. Laboratory tests for blood samples were performed and pancreatic tissue was also evaluated histopathologically. Results: Leukocyte, blood sugar, serum glutamic oxaloacetic transaminase, lactate dehydrogenase, amylase, C-reactive protein, and base excess parameters were evaluated. The values in Groups 2, 3, and 4 were found to be significantly higher than those in the control group, except for leukocyte count and base excess (p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683, respectively). Histopathological results demonstrated significant differences between the groups. Highest pathological damage scores were observed in Groups 3 and 4. Conclusion: Among different theories for the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, elevated intraductal hydrostatic pressure was observed to be the main underlying cause.
dc.identifier.citationBozkurt S., GUNER A., Kadioglu H., KECE C., REIS E., COSKUN H., -The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats-, TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.24, ss.469-475, 2013
dc.identifier.doi10.4318/tjg.2013.0654
dc.identifier.pubmed24623284
dc.identifier.scopus84894170085
dc.identifier.trdizinISSN: 1300-4948 / 2148-5607
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26452
dc.identifier.wosWOS:000331851200003
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida0ee855e-be82-4172-abc1-27ce83bcbee8
local.publication.isinternational1
relation.isAuthorOfPublication37884d0a-1996-406a-8ac4-54476a399574
relation.isAuthorOfPublication1eb651b7-defd-4a5e-8c7c-2f30a7a38cb4
relation.isAuthorOfPublication1bd032a1-7caa-452a-9d53-2967e698fb5f
relation.isAuthorOfPublication.latestForDiscovery1bd032a1-7caa-452a-9d53-2967e698fb5f
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