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Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery

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2016-05-01T00:00:00Z

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YAMAÇ, AYLİN HATİCE
Kucukbuzcu, Sitki
OZANSOY, MEHMET
Gok, Ozlem
Oz, Kursat
Erturk, Mehmet
Yilmaz, Emre
Ersoy, Burak
ZEYBEK, RAHMİ
Goktekin, Omer

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Abstract

Background: Postoperative atrial fibrillation (POAF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. The expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF. So far, information is lacking about the relationship between SIRT1 regulating micro RNAs (miRs), SIRT1 protein and the occurrence of POAF.

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YAMAÇ A. H. , Kucukbuzcu S., OZANSOY M., Gok O., Oz K., Erturk M., Yilmaz E., Ersoy B., ZEYBEK R., Goktekin O., et al., -Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery-, CARDIOVASCULAR PATHOLOGY, cilt.25, ss.232-236, 2016
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