Publication:
Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis

Simple item page
dc.contributor.authorBasaranoglu, METİN
dc.contributor.authorBasaranoglu, GÖKÇEN
dc.contributor.institutionauthorBAŞARANOĞLU, METİN
dc.contributor.institutionauthorBAŞARANOĞLU, GÖKÇEN
dc.date.accessioned2019-10-05T21:13:42Z
dc.date.available2019-10-05T21:13:42Z
dc.date.issued2011-09-28
dc.description.abstractChronic hepatitis due to any cause leads to cirrhosis and end-stage liver disease. A growing body of literature has also shown that fatty liver due to overweight or obesity is a leading cause of cirrhosis. Due to the obesity epidemic, fatty liver is now a significant problem in clinical practice. Steatosis has an impact on the acceleration of liver damage in patients with chronic hepatitis due to other causes. An association between hepatitis C virus (HCV) infection, steatosis and the onset of insulin resistance has been reported. Insulin resistance is one of the leading factors for severe fibrosis in chronic HCV infections. Moreover, hyperinsulinemia has a deleterious effect on the management of chronic HCV. Response to therapy is increased by decreasing insulin resistance by weight loss or the use of thiazoli-denediones or metfornnin. The underlying mechanisms of this complex interaction are not fully understood. A direct cytopathic effect of HCV has been suggested. The genomic structure of HCV (suggesting that some viral sequences are involved in the intracellular accumulation of triglycerides), lipid metabolism, the molecular links between the HCV core protein and lipid droplets (the core protein of HCV and its transcriptional regulatory function which induce a triglyceride accumulation in hepatocytes) and increased neolipogenesis and inhibited fatty acid degradation in mitochondria have been investigated. (C) 2011 Baishideng. All rights reserved.
dc.identifier
dc.identifier.citationBasaranoglu M., Basaranoglu G., -Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis-, WORLD JOURNAL OF GASTROENTEROLOGY, cilt.17, ss.4055-4062, 2011
dc.identifier.doi10.3748/wjg.v17.i36.4055
dc.identifier.pubmed
dc.identifier.scopus80155190150
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6813
dc.identifier.urihttps://www.wjgnet.com/1007-9327/full/v17/i36/4055.htm
dc.identifier.wosWOS:000296871300001
dc.language.isoen
dc.subjectgastroenterology
dc.titlePathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINTERNATIONAL OPHTHALMOLOGY
local.avesis.idaa436de8-81ea-4487-93ea-ff3ff2bcd016
local.avesis.response6689
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication8a7b20a3-6e3e-4a44-acbf-16854071f233
relation.isAuthorOfPublicationb508b903-f47b-4fb9-b3cb-7765e85e885a
relation.isAuthorOfPublication.latestForDiscoveryb508b903-f47b-4fb9-b3cb-7765e85e885a
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
WJG-17-4055.pdf
Size:
721.59 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler