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Association between human leukocyte antigen gene polymorphisms and multiple EPIYA-C repeats in gastrointestinal disorders.

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dc.contributor.authorSaribas, S
dc.contributor.authorDemiryas, S
dc.contributor.authorUysal, O
dc.contributor.authorYilmaz, E
dc.contributor.authorKepil, N
dc.contributor.authorDemirci, M
dc.contributor.authorCaliskan, R
dc.contributor.authorDinc, HARİKA ÖYKÜ
dc.contributor.authorAkkus, S
dc.contributor.authorGareayaghi, N
dc.contributor.authorKirmusaoglu, S
dc.contributor.authorOzbey, D
dc.contributor.authorTokman, HB
dc.contributor.authorKoksal, SS
dc.contributor.authorTasci, I
dc.contributor.authorKocazeybek, B
dc.contributor.institutionauthorUYSAL, ÖMER
dc.contributor.institutionauthorDİNÇ, HARİKA ÖYKÜ
dc.date.accessioned2020-09-16T20:59:07Z
dc.date.available2020-09-16T20:59:07Z
dc.date.issued2020-08-28T00:00:00Z
dc.description.abstractBackground: Polymorphisms of human leukocyte antigen (HLA) genes are suggested to increase the risk of gastric cancer (GC). Aim: To investigate the HLA allele frequencies of patients with GC relative to a control group in terms of CagA+ multiple (≥ 2) EPIYA-C repeats. Methods: The patient group comprised 94 patients [44 GC and 50 duodenal ulcer (DU) patients], and the control group comprised 86 individuals [(50 non-ulcer dyspepsia patients and 36 people with asymptomatic Helicobacter pylori (H. pylori)]. Polymerase chain reaction was performed for the amplification of the H. pylori cagA gene and typing of EPIYA motifs. HLA sequence-specific oligonucleotide (SSO) typing was performed using Lifecodes SSO typing kits (HLA-A, HLA-B HLA-C, HLA-DRB1, and HLA-DQA1-B1 kits). Results: The comparison of GC cases in terms of CagA+ multiple (≥ 2) EPIYA-C repeats showed that only the HLA-DQB1*06 allele [odds ratio (OR): 0.37, P = 0.036] was significantly lower, but significance was lost after correction (Pc = 0.1845). The HLA-DQA1*01 allele had a high ratio in GC cases with multiple EPIYA-C repeats, but this was not significant in the univariate analysis. We compared allele frequencies in the DU cases alone and in GC and DU cases together using the same criterion, and none of the HLA alleles were significantly associated with GC or DU. Also, none of the alleles were detected as independent risk factors after the multivariate analysis. On the other hand, in a multivariate logistic regression with no discriminative criterion, HLA-DQA1*01 (OR = 1.848), HLA-DQB1*06 (OR = 1.821) and HLA-A*02 (OR = 1.579) alleles were detected as independent risk factors for GC and DU. Conclusion: None of the HLA alleles were detected as independent risk factors in terms of CagA+ multiple EPIYA-C repeats. However, HLA-DQA1*01, HLA-DQB1*0601, and HLA-A*2 were independent risk factors with no criterion in the multivariate analysis. We suggest that the association of these alleles with gastric malignancies is not specifically related to cagA and multiple EPIYA C repeats.
dc.description.sponsorshipİstanbul Üniversitesi
dc.identifier.citationSaribas S., Demiryas S., Yilmaz E., Uysal O., Kepil N., Demirci M., Caliskan R., Dinc H. Ö. , Akkus S., Gareayaghi N., et al., -Association between human leukocyte antigen gene polymorphisms and multiple EPIYA-C repeats in gastrointestinal disorders.-, World journal of gastroenterology, cilt.26, ss.4817-4832, 2020
dc.identifier.doi10.3748/wjg.v26.i32.4817
dc.identifier.pubmed32921959
dc.identifier.urihttp://hdl.handle.net/20.500.12645/19630
dc.identifier.urihttps://www.wjgnet.com/1007-9327/full/v26/i32/4817.htm
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCagA
dc.subjectDuodenal ulcer
dc.subjectEPIYAen
dc.subjectGastric cancer
dc.subjectHelicobacter pylori
dc.subjectHuman leukocyte antigen
dc.titleAssociation between human leukocyte antigen gene polymorphisms and multiple EPIYA-C repeats in gastrointestinal disorders.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4fbf9541-63f3-4619-8e50-7b903a99692f
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication6f44fd83-f5fa-4152-9576-c7c1d7ce6ad1
relation.isAuthorOfPublication.latestForDiscovery19df24c5-c3e8-4158-8eed-717f885c608d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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