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Chemical composition and biological activities of Cypriot propolis

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dc.contributor.authorNALBANTSOY, AYŞE
dc.contributor.authorSARIKAHYA, NAZLI
dc.contributor.authorOzverel, Cenk Serhan
dc.contributor.authorBarlas, Ayse Bercin
dc.contributor.authorKirci, Damla
dc.contributor.authorAKGÜN, İSMAİL HAKKI
dc.contributor.authorYalcin, Tansel
dc.contributor.authorDuven, Gamze
dc.contributor.authorKIŞLA, DUYGU
dc.contributor.authorDEMİRCİ, BETÜL
dc.contributor.authorTOPÇU, GÜLAÇTI
dc.contributor.authorGÖREN, AHMET CEYHAN
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.contributor.institutionauthorGÖREN, AHMET CEYHAN
dc.date.accessioned2021-10-19T20:59:14Z
dc.date.available2021-10-19T20:59:14Z
dc.date.issued2021-09-01T00:00:00Z
dc.description.abstractPropolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. alpha-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36-11.56 mu g/mL; 1.44-9.33 mu g/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 mu g/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 +/- 0.10%) and antimicrobial activities (with a MIC value of 31.2 mu g/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).
dc.identifier.citationNALBANTSOY A., SARIKAHYA N., Ozverel C. S. , Barlas A. B. , Kirci D., AKGÜN İ. H. , Yalcin T., Duven G., KIŞLA D., DEMİRCİ B., et al., -Chemical composition and biological activities of Cypriot propolis-, JOURNAL OF APICULTURAL RESEARCH, 2021
dc.identifier.doi10.1080/00218839.2021.1977028
dc.identifier.scopus85116417655
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29575
dc.identifier.wosWOS:000704263800001
dc.titleChemical composition and biological activities of Cypriot propolis
dc.typeArticle
dspace.entity.typePublication
local.avesis.id22ec011c-2b38-44dd-b6a1-f3ae716452bc
local.publication.isinternational1
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication07fcea81-8515-4cd4-86f2-047fe6b2df71
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
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