Publication: Chemical composition and biological activities of Cypriot propolis
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Date
2021-09-01T00:00:00Z
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NALBANTSOY, AYŞE
SARIKAHYA, NAZLI
Ozverel, Cenk Serhan
Barlas, Ayse Bercin
Kirci, Damla
AKGÜN, İSMAİL HAKKI
Yalcin, Tansel
Duven, Gamze
KIŞLA, DUYGU
DEMİRCİ, BETÜL
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Abstract
Propolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. alpha-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36-11.56 mu g/mL; 1.44-9.33 mu g/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 mu g/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 +/- 0.10%) and antimicrobial activities (with a MIC value of 31.2 mu g/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).
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NALBANTSOY A., SARIKAHYA N., Ozverel C. S. , Barlas A. B. , Kirci D., AKGÜN İ. H. , Yalcin T., Duven G., KIŞLA D., DEMİRCİ B., et al., -Chemical composition and biological activities of Cypriot propolis-, JOURNAL OF APICULTURAL RESEARCH, 2021