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Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children

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dc.contributor.authorKahraman, Feyza Ustabas
dc.contributor.authorVehapoglu, Aysel
dc.contributor.authorOzgen, Ilker Tolga
dc.contributor.authorTerzioglu, Sule
dc.contributor.authorCesur, YAŞAR
dc.contributor.authorDundaroz, Rusen
dc.contributor.institutionauthorVEHAPOĞLU TÜRKMEN, AYSEL
dc.contributor.institutionauthorUSTABAŞ KAHRAMAN, FEYZA
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.contributor.institutionauthorTERZİOĞLU, ŞULE
dc.contributor.institutionauthorCESUR, YAŞAR
dc.contributor.institutionauthorİŞCAN, AKIN
dc.date.accessioned2019-10-05T12:56:57Z
dc.date.available2019-10-05T12:56:57Z
dc.date.issued2015-09-01
dc.description.abstractObjective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.en
dc.identifier10.1007/s12070-012-0561-2
dc.identifier.citationKahraman F. U. , Vehapoglu A., Ozgen I. T. , Terzioglu S., Cesur Y., Dundaroz R., -Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.7, ss.197-202, 2015
dc.identifier.doi10.4274/jcrpe.1930
dc.identifier.pubmed26831553
dc.identifier.scopus84940385361
dc.identifier.trdizinISSN: 1308-5727 / 1308-5735
dc.identifier.trdizinISSN: 1308-5727 / 1308-5735
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1002
dc.identifier.wosWOS:000360842500006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleCorrelation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameINDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
local.avesis.id174e3769-a6eb-4283-82a5-b0a65c02c236
local.avesis.response872
local.org.facultyTıp Fakültesi
local.publication.goal02 - Açlığa Son
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