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Gold(III) compounds-mediated inhibition of lung cancer cell proliferation

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dc.contributor.authorBostancioglu, Rakibe B.
dc.contributor.authorKaya, Murat
dc.contributor.authorKoparal, Ayse T.
dc.contributor.authorBenkli, KADRİYE
dc.contributor.institutionauthorBENKLİ, KADRIYE
dc.date.accessioned2020-10-29T19:58:55Z
dc.date.available2020-10-29T19:58:55Z
dc.date.issued2016-03-01T00:00:00Z
dc.description.abstractResearch on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for cancer cells and exert toxic effects on healthy cells, have a limited advantage, they are the primary treatment modalities for non-small lung cancer. In addition to cytotoxicity, resistance of chemotherapeutics results in failure of treatment. This is why it is of utmost importance to focus on the creation of new chemotherapeutics without toxicity for the successful treatment and improved survival of cancer patients. New gold(III) and Pt(II) compounds were synthesized with a heterocyclic ligand using 2-phenylimidazo[4,5-f][1,10]phenanthroline as a ligand and bis-1,4-di[([1,10] phenanthroline-5-il)amino]-2-buten as a bridge molecule. The characterization of the compounds was carried out using a variety of spectroscopic methods (H-1 NMR, IR, MS, and elemental analysis). Their antiproliferative, antitumoral, and apoptotic activities were determined. IR spectra and NMR results confirmed the formation of dinuclear heterocyclic complexes for two metal complexes. Cytotoxicity studies on lung cancer cells (A549) and healthy cells (CHL) showed a marked increase in cytotoxicity with the use of gold(III) complexes, and especially [Au(L)B](PF6)(2) showed higher cytotoxic and apoptotic features than cisplatin at lower concentrations in cancer cells. These findings have been supported by results from DAPI staining and colorimetric measurement of the caspase-3 enzyme in both cell lines. Compounds showed selective toxicity on the cancer cells. In the light of the high efficacy of our newly synthesized gold complexes, they might be good and promising anticancer agents compared with cisplatin.
dc.identifier.citationBostancioglu R. B. , Kaya M., Koparal A. T. , Benkli K., -Gold(III) compounds-mediated inhibition of lung cancer cell proliferation-, ANTI-CANCER DRUGS, cilt.27, ss.225-234, 2016
dc.identifier.doi10.1097/cad.0000000000000327
dc.identifier.scopus84957841892
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25899
dc.identifier.wosWOS:000373515300009
dc.titleGold(III) compounds-mediated inhibition of lung cancer cell proliferation
dc.typeArticle
dspace.entity.typePublication
local.avesis.id56a00c9b-18ed-42a4-839a-763974537eea
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication7c79666b-9d7a-4020-a3f2-da0a94989b66
relation.isAuthorOfPublication.latestForDiscovery7c79666b-9d7a-4020-a3f2-da0a94989b66
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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