Publication:
Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities

dc.contributor.authorİnal E.
dc.contributor.authorNath E. Ö.
dc.contributor.authorAbudayyak M.
dc.contributor.authorUlusoy Ş.
dc.contributor.authorİnan H. A.
dc.contributor.authorCicek M.
dc.contributor.authorKartal M.
dc.contributor.institutionauthorİNAL, EBRAR
dc.contributor.institutionauthorULUSOY, ŞEYMA
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2023-09-18T21:50:20Z
dc.date.available2023-09-18T21:50:20Z
dc.date.issued2023-12-01
dc.description.abstractThe essential oil (EO) compositions and chemotypes of the important ethnomedicinal plantVitex agnus-castusL. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of theV. agnus-castusEO’sin-vitrocytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits ofV. agnus-castuswere analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of theV. agnus-castus. EOs extracted from Balıkesir region were defined as the \"α-pinene-1,8-cineole\" chemotype, while EOs extracted from İstanbul region were defined as the \"sabinene-1,8-cineole\" chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze thein-vitrocytotoxic effects of flowers. This study is also the first to show thein-vitrocytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent -especially the purple flower’s IC50 is about 4.68 µg/mL on the MCF7 cell line- than İstanbul regions, which might be attributed to the higher amount ofα-pinene, caryophyllene, and limonene content. Our results indicated that theV. agnus-castusEOs, which containα-pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.
dc.identifier.citationİnal E., Nath E. Ö., Abudayyak M., Ulusoy Ş., İnan H. A., Cicek M., Kartal M., "Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities", RECORDS OF NATURAL PRODUCTS, cilt.17, sa.5, ss.904-917, 2023
dc.identifier.doi10.25135/rnp.404.2304.2761
dc.identifier.endpage917
dc.identifier.issn1307-6167
dc.identifier.issue5
dc.identifier.startpage904
dc.identifier.urihttps://avesis.bezmialem.edu.tr/api/publication/03e236e7-a4df-4e55-8227-86e7ef3e777e/file
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38551
dc.identifier.volume17
dc.relation.ispartofRECORDS OF NATURAL PRODUCTS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEczacılık
dc.subjectSağlık Bilimleri
dc.subjectPharmacology and Therapeutics
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectYaşam Bilimleri
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectLife Sciences
dc.titleChemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities
dc.typearticle
dspace.entity.typePublication
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