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Clinical significance of low transaminase levels in children with inflammatory bowel disease

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dc.contributor.authorÇAKIR, MURAT
dc.contributor.authorSag, Elif
dc.contributor.authorDogan, Güzide
dc.contributor.authorUnal, Fatih
dc.contributor.authorKasirga, Erhun
dc.contributor.institutionauthorDOĞAN, GÜZİDE
dc.date.accessioned2021-01-26T20:59:14Z
dc.date.available2021-01-26T20:59:14Z
dc.date.issued2019-04-01T00:00:00Z
dc.description.abstractBackgroundLow alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD), but there has been no study about the frequency and its clinical significance. We aimed to analyze the frequency of LALT, and its clinical significance in children with IBD.MethodsThe study included the 89 patients with IBD without hepatobiliary involvement. LALT was defined as ALT levels <5 U/L. Demographic and clinical findings and outcome of the patients with and without LALT were compared.ResultsLALT was found 47.1% of the patients. At initial examination, it was more common in female patients (92.3 vs. 41.3%, P<0.001) and patients with CD (57.7 vs. 30.2%, P=0.01). 75% of the patients with penetrating Crohn-s disease (CD) had LALT (P=0.002). Hemoglobin (10.42.1 vs. 11.7 +/- 1.9g/dL, P=0.01), folic acid (5.2 +/- 3.3 vs. 8.6 +/- 5.9ng/mL, P=0.02) and serum albumin levels (3.6 +/- 0.8 vs. 4.7 +/- 5g/dL, P=0.002) were significantly low in patients with LALT. LALT was associted with the disease relapse within 2weeks in 12 of the 16 patients with LALT whereas it was seen in 16 of the 73 patients without LALT during the follow-up (75 vs. 21.9%, P<0.001). Additionally, steroid dependency was more common in patients with LALT during the follow-up (62.5 vs. 12.3%, P<0.001).ConclusionsLALT is common in children with IBD especially in CD and associated with low hemoglobin, albumin and folic acid levels. It may be a marker of relapse and steroid dependency.
dc.identifier.citationÇAKIR M., Sag E., Dogan G., Unal F., Kasirga E., -Clinical significance of low transaminase levels in children with inflammatory bowel disease-, WORLD JOURNAL OF PEDIATRICS, cilt.15, ss.143-147, 2019
dc.identifier.doi10.1007/s12519-019-00235-5
dc.identifier.scopus85061774744
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28161
dc.identifier.wosWOS:000466225500006
dc.titleClinical significance of low transaminase levels in children with inflammatory bowel disease
dc.typeArticle
dspace.entity.typePublication
local.avesis.id74d6c500-ae48-4372-a1b9-598b1301f093
local.publication.isinternational1
relation.isAuthorOfPublication1aac0a82-faab-4cf5-a9b7-e66071f6ef88
relation.isAuthorOfPublication.latestForDiscovery1aac0a82-faab-4cf5-a9b7-e66071f6ef88
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