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Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

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2011-04-01T00:00:00Z

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Ozcelik, Berrin
Kartal, MURAT
Orhan, Ilkay

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Abstract

Materials and methods: Antiviral activity of the compounds was tested against DNA virus herpes simplex type 1 and RNA virus parainfluenza (type-3). Cytotoxicity of the compounds was determined using Madin-Darby bovine kidney and Vero cell lines, and their cytopathogenic effects were expressed as maximum non-toxic concentration. Antibacterial activity was assayed against following bacteria and their isolated strains: Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis, although they were screened by microdilution method against two fungi: Candida albicans and Candida parapsilosis.

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Ozcelik B., Kartal M., Orhan I., -Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids-, PHARMACEUTICAL BIOLOGY, cilt.49, ss.396-402, 2011

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