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Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen

dc.contributor.authorAgarwal, Ashok
dc.contributor.authorSelvam, Manesh Kumar Panner
dc.contributor.authorArafa, Mohamed
dc.contributor.authorOkada, Hiroshi
dc.contributor.authorHoma, Sheryl
dc.contributor.authorKilleen, Aideen
dc.contributor.authorBalaban, Basak
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorArmagan, Abdullah
dc.contributor.authorRoychoudhury, Shubhadeep
dc.contributor.authorSikka, Suresh
dc.date.accessioned2020-10-22T21:36:44Z
dc.date.available2020-10-22T21:36:44Z
dc.date.issued2019-11-01T00:00:00Z
dc.description.abstractAccording to the World Health Organization (WHO), oxidative stress (OS) is a significant contributor to male infertility. Seminal OS can be measured by a number of assays, all of which are either costly or time sensitive and/or require large semen volume and complex instrumentation. One less expensive alternative is to quantify the oxidation-reduction potential (ORP) with the MiOXSYS. In this international multi-center study, we assessed whether ORP levels measured by the MiOXSYS could distinguish semen samples that fall within the 2010 WHO normal reference values from those that do not. Semen samples were collected from 2092 patients in 9 countries; ORP was normalized to sperm concentration (mV/10(6) sperm/ml). Only those samples with a concentration >1 x 10(6) sperm ml(-1) were included. The results showed that 199 samples fell within the WHO normal reference range while the remaining 1893 samples did not meet one or more of the criteria. ORP was negatively correlated with all semen parameters (P < 0.01) except volume. The area under the curve for ORP was 0.765. The ORP cut-off value (1.34 mV/10(6) sperm/ml) was able to differentiate specimens with abnormal semen parameters with 98.1% sensitivity, 40.6% specificity, 94.7% positive predictive value (PPV) and 66.6% negative predictive value (NPV). When used as an adjunct to traditional semen analysis, ORP levels may help identify altered functional status of spermatozoa caused by OS in cases of idiopathic male infertility and in male partners of couples suffering recurrent pregnancy loss, and thereby directing these men to relevant medical therapies and lifestyle modifications.
dc.identifier.citationAgarwal A., Selvam M. K. P. , Arafa M., Okada H., Homa S., Killeen A., Balaban B., Saleh R., Armagan A., Roychoudhury S., et al., -Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen-, ASIAN JOURNAL OF ANDROLOGY, cilt.21, ss.565-569, 2019
dc.identifier.doi10.4103/aja.aja_5_19
dc.identifier.pubmed31006711
dc.identifier.scopus85074305716
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24875
dc.identifier.wosWOS:000502802000006
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMulti-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen
dc.typeArticle
dspace.entity.typePublication
local.avesis.idf1f707a6-6fed-410d-b330-c07bb607ed46
local.publication.isinternational1
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