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Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis

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Ozturk, Erdogan
Surucu, Murat
Karaman, Abdurrahman
ŞAMDANCI, EMİNE
Fadillioglu, Ersin

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Background: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome.

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Ozturk E., Surucu M., Karaman A., ŞAMDANCI E., Fadillioglu E., -Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis-, JOURNAL OF SURGICAL RESEARCH, cilt.187, ss.610-615, 2014

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