Publication: Assessment of Liver Fibrosis with Diffusion-Weighted Magnetic Resonance Imaging Using Different b-values in Chronic Viral Hepatitis
dc.contributor.author | KOCAKOÇ, ERCAN | |
dc.contributor.author | Bakan, Ayse Ahsen | |
dc.contributor.author | Poyrazoglu, Orhan Kursat | |
dc.contributor.author | Dagli, Adile Ferda | |
dc.contributor.author | Gul, Yeliz | |
dc.contributor.author | Cicekci, Mehtap | |
dc.contributor.author | BAHÇECİOĞLU, İBRAHİM HALİL | |
dc.contributor.institutionauthor | KOCAKOÇ, ERCAN | |
dc.date.accessioned | 2020-10-22T20:21:02Z | |
dc.date.available | 2020-10-22T20:21:02Z | |
dc.date.issued | 2015-01-01T00:00:00Z | |
dc.description.abstract | Objective: To examine the effectiveness of apparent diffusion coefficient (ADC) values and to compare the reliability of different b-values in detecting and identifying significant liver fibrosis. Subjects and Methods: There were 44 patients with chronic viral hepatitis (CVH) in the study group and 30 healthy participants in the control group. Diffusion-weighted magnetic resonance imaging (DWI) was performed before the liver biopsy in patients with CVH. The values of ADC were measured with 3 different b-values (100, 600, 1,000 s/mm(2)). In addition, liver fibrosis was classified using the modified Ishak scoring system. Liver fibrosis stages and ADC values were compared using areas under the receiver-operating characteristic (ROC) curve. Results: The study group-s mean ADC value was not statistically significantly different from the control group-s mean ADC value at b = 100 s/mm(2) (3.69 +/- 0.5 x 10(-3) vs. 3.7 +/- 0.3 x 10(-3) mm(2)/s) and b = 600 s/mm(2) (2.40 +/- 0.3 x 10(-3) vs. 2.5 +/- 0.5 x 10(-3) mm(2)/s). However, the study group-s mean ADC value (0.99 +/- 0.3 x 10(-3) mm(2)/s) was significantly lower than that of the control group (1.2 +/- 0.1 x 10(-3) mm(2)/s) at b = 1,000 s/mm(2). With b = 1,000 s/mm(2) and the cutoff ADC value of 0.0011 mm(2)/s for the diagnosis of liver fibrosis, the mean area under the ROC curve was 0.702 +/- 0.07 (p = 0.0015). For b = 1,000 s/mm(2) and the cutoff ADC value of 0.0011 mm(2)/s to diagnose significant liver fibrosis (Ishak score = 3), the mean area under the ROC curve was 0.759 +/- 0.07 (p = 0.0001). Conclusion: Measurement of ADC values by DWI was effective in detecting liver fibrosis and accurately identifying significant liver fibrosis when a b-value of 1,000 s/mm(2) was used. (C) 2015 S. Karger AG, Basel | |
dc.identifier.citation | KOCAKOÇ E., Bakan A. A. , Poyrazoglu O. K. , Dagli A. F. , Gul Y., Cicekci M., BAHÇECİOĞLU İ. H. , -Assessment of Liver Fibrosis with Diffusion-Weighted Magnetic Resonance Imaging Using Different b-values in Chronic Viral Hepatitis-, MEDICAL PRINCIPLES AND PRACTICE, cilt.24, ss.522-526, 2015 | |
dc.identifier.doi | 10.1159/000434682 | |
dc.identifier.pubmed | 26183515 | |
dc.identifier.scopus | 84946498694 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/24690 | |
dc.identifier.uri | https://www.karger.com/Article/FullText/434682 | |
dc.identifier.wos | WOS:000364216200004 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Hepatitis | |
dc.title | Assessment of Liver Fibrosis with Diffusion-Weighted Magnetic Resonance Imaging Using Different b-values in Chronic Viral Hepatitis | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | dbf671d8-af02-4201-9c37-660c1fb2e9f9 | |
local.indexed.at | PubMed | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.goal | 03 - Sağlık ve Kaliteli Yaşam | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 11dac5b9-c1dc-4ca8-9783-96ae99d32e20 | |
relation.isAuthorOfPublication.latestForDiscovery | 11dac5b9-c1dc-4ca8-9783-96ae99d32e20 | |
relation.isGoalOfPublication | 9c198c48-b603-4e2f-8366-04edcfc1224c | |
relation.isGoalOfPublication.latestForDiscovery | 9c198c48-b603-4e2f-8366-04edcfc1224c |
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