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Body Mass Index and Mild Cognitive Impairment Among Middle-Aged and Older Adults from Low- and Middle-Income Countries.

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dc.contributor.authorSmith, Lee
dc.contributor.authorShin, Jae Il
dc.contributor.authorOh, Hans
dc.contributor.authorCarmichael, Christina
dc.contributor.authorJacob, Louis
dc.contributor.authorStefanac, Sinisa
dc.contributor.authorLindsay, Rosie K
dc.contributor.authorSoysal, PINAR
dc.contributor.authorVeronese, Nicola
dc.contributor.authorTully, Mark A
dc.contributor.authorButler, Laurie
dc.contributor.authorBarnett, Yvonne
dc.contributor.authorKoyanagi, Ai
dc.contributor.institutionauthorSOYSAL, PINAR
dc.date.accessioned2021-12-14T20:59:19Z
dc.date.available2021-12-14T20:59:19Z
dc.date.issued2021-12-10T00:00:00Z
dc.description.abstractBackground: The effect of weight modification on future dementia risk is currently a subject of debate and may be modified by age. Objective: The aim of the present study was to investigate the association between body mass index (BMI) status with mild cognitive impairment (MCI) (a preclinical stage of dementia) in middle-aged and older adults residing in six low- and middle-income countries using nationally representative data. Methods: Cross-sectional data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. BMI (kg/m2) was based on measured weight and height and categorized as: underweight (<18.5), normal (18.5-24.9), overweight (25.0-29.9), and obese (≥30.0). Multivariable logistic regression analysis and meta-analysis were conducted to assess associations. Results: Data on 32,715 individuals aged ≥50 years with preservation in functional abilities were analyzed [mean (SD) age 62.1 (15.6) years; 51.7% females]. Among those aged 50-64 years, compared to normal weight, underweight (OR = 1.44; 95% CI = 1.14-1.81), overweight (OR = 1.17; 95% CI = 1.002-1.37), and obesity (OR = 1.46; 95% CI = 1.09-1.94) were all significantly associated with higher odds for MCI. In those aged ≥65 years, underweight (OR = 0.71; 95% CI = 0.54-0.95) and overweight (OR = 0.72; 95% CI = 0.55-0.94) were associated with significantly lower odds for MCI, while obesity was not significantly associated with MCI. Conclusion: The results of the study suggest that the association between BMI and MCI is likely moderated by age. Future longitudinal studies are required to confirm or refute the present findings before recommendations for policy and practice can be made.
dc.identifier.citationSmith L., Shin J. I. , Oh H., Carmichael C., Jacob L., Stefanac S., Lindsay R. K. , Soysal P., Veronese N., Tully M. A. , et al., -Body Mass Index and Mild Cognitive Impairment Among Middle-Aged and Older Adults from Low- and Middle-Income Countries.-, Journal of Alzheimer-s disease : JAD, 2021
dc.identifier.doi10.3233/jad-215345
dc.identifier.pubmed34897093
dc.identifier.scopus85124172746
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29757
dc.identifier.wosWOS:000752449800013
dc.subjectAged
dc.subjectbody mass index
dc.subjectcognitive dysfunction
dc.subjectobesity
dc.titleBody Mass Index and Mild Cognitive Impairment Among Middle-Aged and Older Adults from Low- and Middle-Income Countries.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4e014516-c1a8-42cb-ac02-1e88afa78d25
local.publication.isinternational1
relation.isAuthorOfPublication0e36986e-d71d-4579-a395-877af097ade5
relation.isAuthorOfPublication.latestForDiscovery0e36986e-d71d-4579-a395-877af097ade5
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