Publication: Hemostatic Efficacy of a Traditional Medicinal Plant Extract (Ankaferd Blood Stopper) in Bleeding Control
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Date
2015-05-01T00:00:00Z
Authors
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Sogut, Ozgur
Erdogan, Mehmet Ozgur
Kose, Rustu
BOLEKEN, MEHMET EMİN
Kaya, Halil
Gokdemir, Mehmet Tahir
ÖZGÖNÜL, ABDULLAH
İYNEN, İSMAİL
Albayrak, Levent
DOKUZOĞLU, MEHMET AKİF
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Abstract
The aim of this study is to assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS) on rats using a tail bleeding model. Wistar rats were randomized into 4 groups of 9 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. Without heparin pretreatment, ABS shortened hemostasis time by 1.57 minutes and reduced the amount of bleeding by 0.85 g. With heparin pretreatment, ABS shortened hemostasis time by 3.29 minutes and reduced the amount of bleeding by 1.32 g. The ABS was more effective than saline irrigation for treating tail tip bleeding in rats, with or without heparin pretreatment, while also using a compressive dressing.
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Sogut O., Erdogan M. O. , Kose R., BOLEKEN M. E. , Kaya H., Gokdemir M. T. , ÖZGÖNÜL A., İYNEN İ., Albayrak L., DOKUZOĞLU M. A. , -Hemostatic Efficacy of a Traditional Medicinal Plant Extract (Ankaferd Blood Stopper) in Bleeding Control-, CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.21, ss.348-353, 2015