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Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart

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dc.contributor.authorÜSTÜNOVA, SAVAŞ
dc.contributor.authorTAKIR, SELÇUK
dc.contributor.authorYILMAZER, NADİM
dc.contributor.authorBulut, Huri
dc.contributor.authorALTINDİREK, Didem
dc.contributor.authorHATIRNAZ NG, Özden
dc.contributor.authorTansel, Cihan Demirci
dc.contributor.authorDogan, B. Sonmez Uydes
dc.contributor.authorÖZBEK, Uğur
dc.contributor.authorARMUTAK, Elif İlkay
dc.contributor.authorGurevin, Ebru Gurel
dc.contributor.institutionauthorÜSTÜNOVA, SAVAŞ
dc.date.accessioned2020-10-22T18:34:54Z
dc.date.available2020-10-22T18:34:54Z
dc.date.issued2020-09-01T00:00:00Z
dc.description.abstractBackground/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfiision (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 mu M) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H2S and NO increase each other-s production suggesting their interaction and cooperation in cardioprotection against I/R injury.
dc.description.sponsorshipİstanbul Üniversitesi
dc.identifier.citationÜSTÜNOVA S., TAKIR S., YILMAZER N., Bulut H., ALTINDİREK D., HATIRNAZ NG Ö., Tansel C. D. , Dogan B. S. U. , ÖZBEK U., ARMUTAK E. İ. , et al., -Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart-, IN VIVO, cilt.34, ss.2507-2516, 2020
dc.identifier.doi10.21873/invivo.12067
dc.identifier.pubmed32871779
dc.identifier.scopus85090182315
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24204
dc.identifier.urihttp://iv.iiarjournals.org/content/34/5/2507.long
dc.identifier.wosWOS:000574979000007
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydrogen Sulphide
dc.subjectIsolated Rat Heart
dc.subjectNitric Oxide
dc.subjectIschemia
dc.subjectReperfusion Injury
dc.titleHydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart
dc.typeArticle
dspace.entity.typePublication
local.avesis.id929fafa1-cfc0-4a71-aa4d-5f10464fb486
local.publication.isinternational1
relation.isAuthorOfPublicationbebec550-3712-466a-8e2d-8f90006e62f6
relation.isAuthorOfPublication.latestForDiscoverybebec550-3712-466a-8e2d-8f90006e62f6
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