Publication:
Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart

Loading...
Thumbnail Image

Date

2020-09-01T00:00:00Z

Authors

ÜSTÜNOVA, SAVAŞ
TAKIR, SELÇUK
YILMAZER, NADİM
Bulut, Huri
ALTINDİREK, Didem
HATIRNAZ NG, Özden
Tansel, Cihan Demirci
Dogan, B. Sonmez Uydes
ÖZBEK, Uğur
ARMUTAK, Elif İlkay

Journal Title

Journal ISSN

Volume Title

Publisher

Research Projects

Organizational Units

Journal Issue

Metrics

Search on Google Scholar

Abstract

Background/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfiision (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 mu M) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H2S and NO increase each other-s production suggesting their interaction and cooperation in cardioprotection against I/R injury.

Description

Keywords

Hydrogen Sulphide, Isolated Rat Heart, Nitric Oxide, Ischemia, Reperfusion Injury

Citation

ÜSTÜNOVA S., TAKIR S., YILMAZER N., Bulut H., ALTINDİREK D., HATIRNAZ NG Ö., Tansel C. D. , Dogan B. S. U. , ÖZBEK U., ARMUTAK E. İ. , et al., -Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart-, IN VIVO, cilt.34, ss.2507-2516, 2020
Page Views

0

File Downloads

5

Sustainable Development Goals