Person: GÜNEŞ BAYIR, AYŞE
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Publication Metadata only Handbook of Oxidative Stress in Cancer: Mechanistic Aspects(2021-05-01T00:00:00Z) Güneş Bayır, Ayşe; GÜNEŞ BAYIR, AYŞECarcinogenesis is a complex and multistep process ending with metastasis. Mainly, gene and metabolic pathways include endogenous and signaling molecular pathways which cause a rise in cell proliferation and a decrease in cell death. Apoptosis is a programmed cell death which can happen with extracellular and intracellular signals. Generally, the extrinsic and the intrinsic pathways are known as the two apoptotic pathways. The excessive ROS production in cancer cells can stimulate the cell proliferation, the DNA mutations, and the formation of drug-resistant cells. It may also ensure a basisfor thedevelopment of novel therapeutic strategies that take advantage of overgenerating ROS to destroy cancer cells. As the ROS-producing agents have toxic side effects and potential mutagenic impact, caution should be exercised during their use. In this chapter, focus will be on ROS generation, the relationship between apoptosis and ROS, and the key apoptotic mechanisms and their regulations.KeywordsApoptosisReactive oxygen speciesCancer cellsCarcinogenesisPublication Metadata only RECENT STUDIES IN HEALTH SCIENCES(2020-12-01T00:00:00Z) Yılmaz, Solmaz Ece; Güneş Bayır, Ayşe; Mendeş, Beyza; GÜNEŞ BAYIR, AYŞEPublication Metadata only Dietary Interventions in Gastrointestinal Diseases(2019-01-01T00:00:00Z) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HÜRİYE ŞENAY; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAYPublication Metadata only Sağlık Bilimlerinde Araştırma ver Değerlendirmeler(2021-05-01T00:00:00Z) Çelik, Meryem Beyza; Demir, Esmanur; Güneş Bayır, Ayşe; GÜNEŞ BAYIR, AYŞEPublication Metadata only Sağlık Bilimlerinde Araştırma ve Değerlendirmeler(2021-05-01T00:00:00Z) Usul, Melisa; Sevim, Merve; Güneş Bayır, Ayşe; GÜNEŞ BAYIR, AYŞEPublication Metadata only RECENT STUDIES IN HEALTH SCIENCES(2020-12-01T00:00:00Z) Mendeş, Beyza; Güneş Bayır, Ayşe; Yılmaz, Solmaz Ece; GÜNEŞ BAYIR, AYŞEPublication Metadata only Handbook of Oxidative Stress in Cancer: Therapeutic Aspects(2022-04-01T00:00:00Z) Munsi, Anjana; Güneş Bayır, Ayşe; GÜNEŞ BAYIR, AYŞEPublication Metadata only Sağlık Bilimlerinde Araştırma ve Değerlendirmeler(2021-05-01T00:00:00Z) Özer, Sema Nur; Gökyar, Nurevşan; Ersarı, Tülay; Güneş Bayır, Ayşe; GÜNEŞ BAYIR, AYŞEPublication Metadata only IMPORTANT ISSUES IN HEALTH SCIENCES(2021-05-01T00:00:00Z) Güneş Bayır, Ayşe; Sevim, Merve; GÜNEŞ BAYIR, AYŞE