2014-06-28, IDIZ, O, Aysan, E, FIRAT, D, ERSOY, YELİZ EMİNE, CENGIZ, MB, AKBULUT, H, ISıK, A, MUSLUMANOGLU, M, AYŞAN, MUSTAFA ERHAN, ERSOY, YELIZ EMINE

We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy. Material/Method: We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically. Results: The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05). Conclusions: Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.

2018-02-01, MALYA, FATMA ÜMİT, KADIOGLU, HÜSEYİN, BEKTASOGLU, HÜSEYİN KAZIM, Gucin, ZÜHAL, YILDIZ, S, GUZEL, MEHMET, ERDOGAN, EZGİ BAŞAK, YUCEL, S, ERSOY, YELİZ EMİNE, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, BEKTAŞOĞLU, HÜSEYİN KAZIM, GÜCİN, ZÜHAL, YILDIZ, ŞEYMA, GÜZEL, MEHMET, ERDOĞAN, EZGİ BAŞAK, ERSOY, YELIZ EMINE

Abstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients.

2013-01-01, Kadioglu, HÜSEYİN, YILDIZ, S, ERSOY, YELİZ EMİNE, YÜCEL, S, MUSLUMANOGLU, M, KADIOĞLU, HÜSEYİN, ERSOY, YELIZ EMINE

An unusual case caused by a common reason: Mondor’s disease by oral contraceptives

2018-10-01T00:00:00Z, Yücesan, Emrah, Başoğlu, Harun, Özten Kandaş, Nur, Kanımdan, Ebru, Akbaş, Fahri, Ersoy, Yeliz Emine, Ayşan, Erhan, GÖNCÜ, BEYZA SERVET, AKBAŞ, FAHRİ, ERSOY, YELIZ EMINE

Objective: Hypothyroidism is a clinical condition that affects all age groups. Generally, lifelong medication is required for the treatment. Despite treatment, symptoms that are related to hormone insufficiency and side effects due to long-term medication can be seen. As an alternative approach, thyroid tissue transplantation may be useful, because of its potential to elevate the thyroid hormone levels and thus increase daily quality of life for the patients. Our aim in this study was to detect the in vitro optimal microencapsulation conditions for thyroid tissues with a biocompatible polymer to avoid immune rejection following transplantation. Material and Methods: Thyroid tissues were isolated mechanically, and followed-up in two groups; tissue and capsulated tissue culture. In-vitro capsule formation and morphology were screened using brightfield microscopy and T3 and T4 levels were evaluated biochemically throughout 60 days. Results: T3 and T4 levels were screened from collected medium samples at day 3., 9., 12., 15., 30., 45., 60.. In capsuled tissues T3 level was detected higher than the non-capsuled and negative control tissues from day 15. However, T4 level was stable for 60 days.

2012-11-13, SARI, S, Aysan, E, MUSLUMANOGLU, M, ERSOY, YELİZ EMİNE, BEKTASOGLU, HÜSEYİN KAZIM, YARDıMCı, ERKAN, AYŞAN, MUSTAFA ERHAN, ERSOY, YELIZ EMINE, BEKTAŞOĞLU, HÜSEYİN KAZIM, YARDIMCI, ERKAN

Background: We aimed to minimalize operative complications by spraying of methylene blue stain on thyroid glands and the perithyroidal area. Material and methods: The intra-operative methylene blue spraying technique was used prospectively on a total of 56 patients who had undergone primary (not recurrent) thyroid surgery for a variety of thyroid diseases. Bilateral total thyroidectomy was performed in all cases. After superior but before inferior pole ligation, 0.5ml of methylene blue was sprayed over the thyroid lobe and perilober area. Tissues, especially parathyroides, the recurrent laryngeal nerve, and the inferior thyroid artery, were identified and evaluated. Results: Recurrent laryngeal nerve and arteries were not stained and thus they remained white in all cases while all other tissues were stained blue. Within three minutes parathyroid glands washed out the blue stain and the original yellow color was regained. Thyroid tissue wash-out time was not less than 15 minutes; perithyroideal muscles, tendinous and lipoid structures took no less than 25 minutes. Conclusion: The safety of intravascular methylene blue guidance on thyroid surgery is known. This research demonstrates the effectiveness of the spraying technique, a new technique which ensures not only identification of parathyroid glands within three minutes, but also identification of recurrent laryngeal nerves and inferior thyroid arteries.

2018-02-01, Malya, FATMA ÜMİT, Kadioglu, HÜSEYİN, Hasbahçeci, Mustafa, Dolay, KEMAL, Guzel, MEHMET, Ersoy, YELİZ EMİNE, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, DOLAY, KEMAL, GÜZEL, MEHMET, ERSOY, YELIZ EMINE

Objective To compare urinary iodine excretion levels in patients with breast cancer and control subjects. Methods In this prospective pilot study, patients with breast cancer and normal controls were recruited. Age and menopausal status were recorded. Levels of serum thyroid-stimulating hormone, blood urea nitrogen and creatinine and urine iodine concentration (UIC) were measured. UIC levels were divided into three categories: low (<100 µg/l), normal (100-200 µg/l) or high (>200 µg/l). Results A total of 24 patients with breast cancer and 48 controls were included in the study. There were no statistically significant differences between the two groups with regard to thyroid-stimulating hormone, blood urea nitrogen or creatinine levels. When considered overall, there was no statistical difference in UIC between patients and controls. However, comparisons within each category (low, normal or high UIC) showed a significantly higher percentage of patients with breast cancer had a high UIC compared with controls. Conclusions A high UIC was seen in a significantly higher percentage of patients with breast cancer than controls. UIC may have a role as a marker for breast cancer screening. Further studies evaluating UIC and iodine utilization in patients with breast cancer are warranted.

2013-10-01, ERGÜN, SELMA, ERSOY, YELIZ EMINE, ERGÜN, SELMA

Reconstruction of large abdominal wall defects is a challenging problem. Various reconstructive techniques have been described in the surgical literature each with its advantages and disadvantages. In this report we describe our experience in treating a patient with large abdominal wall defect by staged abdominal wall reconstruction utilizing prosthetic mesh in conjunction with tissue expanders. A 41-year-old male presented with abdominal pain. Exploratory laparotomy showed perforated appendicitis with intraabdominal abscess of 1,500 mL. Postoperatively, he developed intraperitoneal sepsis. To prevent abdominal compartment syndrome, he was reoperated and left with "open abdomen". After several open abdomen lavages, his abdominal wall defect was allowed to granulate. After epithelization of the defect, the abdominal wall was reconstructed using prosthetic mesh and tissue expanders. The tissue expansion process was well tolerated. We suggest that the use of tissue expanders provides reliable and well-vascularized soft-tissue coverage in abdominal wall reconstruction.

2013-01-01, CIPE, G, Malya, FATMA ÜMİT, HASBAHCECI, M, ERSOY, YELİZ EMİNE, KARATEPE, O, MUSLUMANOGLU, M, MALYA, FATMA ÜMİT, ERSOY, YELIZ EMINE

Jejunogastric intussusception is a rare complication of gastric surgery. It usually presents with severe epigastric pain, vomiting, and hematemesis. A history of gastric surgery can help in making an accurate and early diagnosis which calls forth an urgent surgical intervention. Only reduction or resection with revision of the previously performed anastomosis is the choice which is decided according to the operative findings. We present a case of JGI in a patient with a history of Billroth II operation diagnosed by computed tomography. At emergent laparotomy, an efferent loop type JGI was found. Due to necrosis, resection of the intussuscepted bowel with Roux-en-Y anastomosis was performed. Postoperative recovery was uneventful.

2013-01-01, BOZKURT, SÜLEYMAN, COSKUN, HALİL, Kadioglu, HÜSEYİN, MEMMI, NAİM, CIPE, G, ERSOY, YELİZ EMİNE, LEBE, B, MUSLUMANOGLU, M, BOZKURT, SÜLEYMAN, COŞKUN, HALIL, KADIOĞLU, HÜSEYİN, MEMMİ, NAİM, ERSOY, YELIZ EMINE

A 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.

2019-01-01, Ozkurt, Enver, Yardimci, ERKAN, Tukenmez, Mustafa, Ersoy, YELİZ EMİNE, Yilmaz, Ravza, Cabioglu, Neslihan, Karanlik, Hasan, Kulle, Cemil Burak, Malya, FATMA ÜMİT, Onder, Semen, Gucin, ZÜHAL, Igci, Abdullah, Ozmen, Vahit, Dinccag, Ahmet Sait, Muslumanoglu, Mahmut, YARDIMCI, ERKAN, ERSOY, YELIZ EMINE, MALYA, FATMA ÜMİT, GÜCİN, ZÜHAL

Recent randomized trials have shown that completion axillary lymph node dissection (ALND) is not required in all patients with a positive sentinel lymph node (SLN) who will receive radiation therapy. Although routine intraoperative pathologic assessment (IPA) becomes unnecessary and less indicated by breast surgeons in the United States and some European countries, it is still widely used all around the world. In this prospective study, the feasibility of intraoperative nodal palpation (INP) as opposed to IPA of the SLN has been analyzed. Between March 2014 and June 2015, 305 patients with clinical T1-2/N0 breast cancer from two different breast clinics (cohort A; [n = 225] and cohort B; [n = 80]) who underwent any breast surgery with sentinel lymph node biopsy (SLNB) were included in this study. Surgeons evaluated the SLNs by manual palpation before sending for IPA, and findings compared with the final pathology. The positive predictive values (PPV) of INP and IPA were 81.8% and 97.9%, respectively, whereas the negative predictive values (NPV) of INP and IPA were 83% and 92.4%. The accuracies of INP and IPA were 82.6% and 94.1%, respectively. If patients with SLNB including micrometastasis were also considered in the final pathologic assessment (FPA) (-) group that would not require a further axillary dissection, the revised NPV of INP and FPA were found to be 92.6% and 98.1%, respectively. The revised accuracy of INP also found to be increase to 86.9%. Our study, which is the only prospective one about palpation of dissected SLNs in the literature, suggests that INP can help to identify patients who do not need ALND, which encourages omitting IPA in cT1-2 N0 breast cancer.