Bezmialem Science Koleksiyonu
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- PublicationOpen AccessEmpathic Tendencies and Attitudes Toward People with Disabilities in Healthy Developing Children and Their Relationship Between Empathic Tendencies of Parents(2022-10-01) Sap R.; Özkan Ş.; Uğurlu Ü.; ÖZKAN, ŞÜHEDA; UĞURLU, ÜMITObjective: This study was conducted to investigate empathic tendencies and attitudes toward people with disabilities in healthy developing children and the relationship between their parents’ empathic tendencies. Methods: Fifty-fourth grade primary school students and their parents were included in this study. KA-SI Empathic Tendency Scale-Child Form (KA-SI), Chedoke-Mcmaster Attitudes Towards Children with Handicaps Scale and Empathetic Tendency Scale (ETS) for parents were used. Results: When the total scores were considered, there was a moderate correlation between children's empathic tendencies and attitudes towards the disabled (r=0.594; p<0.0001). Any correlation was not observed among the empathic tendencies of parents and children’s empathic tendencies and attitudes towards the disabled (r=0.263 and r=0.270; p>0.05, respectively). Parents with a college degree had a higher level of empathy in their children (p<0.05). Conclusion: In this study, which examined the empathic tendencies of normally developed children and their attitudes towards the disabled and their relationship with the empathic tendencies of their parents, it was concluded that the increase in empathic tendencies of children supported their attitudes towards the disabled in a moderately positive way. The relationship between the level of education of parents and the increase in empathic tendencies of children may indicate the importance of education in this regard. Ensuring the development of children in terms of empathy and positive attitudes and improving the education levels of parents can support the participation of people with disabilities into life by supporting positive attitudes towards them.
- PublicationOpen AccessThe Role of Post-treatment FDG-PET/CT Scanning after the First-line Chemotherapy in Predicting Prognosis in Patients with Hodgkin Disease and High-grade Non-Hodgkin Lymphoma: A Comparative Study with Clinical Prognostic Risk Scoring Data(2022-06-01T00:00:00Z) ERDOĞAN, EZGİ BAŞAK; Guner, Sebnem; SÖNMEZOĞLU, KERİM; ERDOĞAN, EZGİ BAŞAKObjective: We aimed to evaluate the role of fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) performed after the first-line therapy in predicting prognosis of lymphomas and compare the results with the pretreatment prognostic risk scoring (PRS) indices. Methods: One hundred three patients with histopathologically confirmed Hodgkin (HD) and high-grade non-Hodgkin lymphoma (NHL) were included in the study. All patients received FDG-PET/CT imaging after the end of primary treatment. After intraveneus application of FDG, whole body PET/CT from the upper thigh to the vertex was performed. Results: The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of post-treatment FDG-PET/CT imaging in predicting remission status were 73.6%, 91.6%, 88%, 66.6%, and 94.0%, respectively. Those values were 63.0%, 62.0%, 62.0%, 27%, and 88.0% respectively, for pretreatment clinical risk scoring (p<0.001). Among the patients with positive PET scans after ending of the first-line therapy, 71.4% of those with only single lymph node station involvement stayed in remission, whereas 12.5% of the patients who had involvement of multiple lymph node stations and 16.7% of the patients who had extranodal disease could sustain in remission (p<0.05). Conclusion: We found that FDG-PET performed after first-line therapy was superior to clinical PRS systems in predicting prognosis of HD and NHL disease as conclusions. Although it was more successful to predict patients who would stay in remission with its high NPV, FDG-PET/CT imaging had a lower PPV due to false positive results. However, persistent FDG uptake in multinodal lymphatic stations and/or in extranodal sites on the post-therapy PET/CT scanning was more suggestive in predicting risk for recurrence.
- PublicationOpen AccessA Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel(2022-06-01T00:00:00Z) Gokkaya, Bengisu; Atasoy, Sezen; ÇIRAKOĞLU, AYŞE; ARGÜDEN, YELDA; KURU, RAHİYE DİLHAN; YILMAZ, ŞÜKRİYE; ÖNGÖREN, ŞENİZ; DEVİREN, AYHAN; ATASOY, SEZENObjective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. For diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyotype or unsuccessful karyotyping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenetic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.
- PublicationOpen AccessScreening of mecC Gene in Methicillin Resistant Staphylococcus aureus Isolates(2022-04-01T00:00:00Z) Ceylan, Ayse Nur; SÜMBÜL, BİLGE; DOYMAZ, Mehmet Ziya; SÜMBÜL, BİLGE; DOYMAZ, MEHMET ZIYAObjective: The diagnosis and treatment of mecC positive methicillin resistant Staphylococcus aureus (MRSA) isolates pose a significant problem in clinical microbiology and infectious disease practices. The studies on the frequency of mecC positive isolates in Turkey is rather scarce. In the present study, we aimed to investigate the presence of mecA, mecC, spa and pvu genes in MRSA strains isolated from various clinical specimens submitted to Clinical Microbiology Laboratories of Bezmialem Vakıf Hospital. Methods: We performed nucleic acid extraction and multiplex polymerase chain reaction (PCR) to 126 MRSA strains to detect mecC, mecA, spa and pvl genes. Results: According to the multiplex PCR results of 126 MRSA strains studied, 126 (100%) had mecA, 107 (85%) had spa, and 3 (2%) had pvl genes. We performed another polymerase chain reaction protocol and spa genes were identified in 19 of specimens, which were found negative priorly. Conclusion: Considering the factors that a university medical center where the study was conducted provided a tertiary healthcare service to a large metropolitan area in Istanbul and none of the isolates carried mecC gene might indicate that mecC gene carrying MRSA isolates did not pose a significant public health threat in Turkey.
- PublicationOpen AccessInvestigation of Bioactive Components, Antioxidant and Antimicrobial Activities of Traditional Turkish Beverage Hardaliye(2022-01-01T00:00:00Z) POLAT SARI, SİLVA; DİNÇ, HARİKA ÖYKÜ; BÜYÜKKILIÇ ALTINBAŞAK, BETÜL; YÜKSEL MAYDA, PELİN; AKGÜL, ÖZER; SAPMAZ, BURCU; ÇALIŞKAN, REYHAN; ÖNER, YAŞAR ALİ; DİNÇ, HARİKA ÖYKÜ; BÜYÜKKILIÇ ALTINBAŞAK, BETÜLObjective: In our study, it was aimed to make the chemical analysis of hardaliye products (H1 and H2), which are commercially available by different manufacturers, and to examine their antioxidant and antimicrobial activities. Methods: Antioxidant activity, organic acid and phenolic compounds, and antimicrobial activity in Hardaliye products (H1 and H2) were determined by using 1.1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, [liquid chromatographyhigh resolution mass spectrometry (LC-HR/MS)] and liquid microdilution methods, respectively. Results: Ascorbic acid and fumaric acid from organic acids were determined by chemical analysis of hardaliye samples by LC-HR/ MS method. While ascorbic acid concentrations were 21.295 mg/L and 26.84 mg/L in H1 and H2, respectively, fumaric acid concentrations were 59.55 mg/L in H1, and 224.562 mg/L in H2. While the phenolic component with the highest concentration in H1 was resveratrol (44.57 mg/L), it was observed that the phenolic component with the highest concentration in H2 was p-coumaric acid (31.87 mg/L). In terms of antioxidant activity, diphenyl-2- picrylhydrazylfree radical scavenging activity of hardaliye samples was determined as 2.07±0.004% and 2.49±0.004% in H1 and H2, respectively. It was determined that hardaliye samples showed inhibitory effect [H1 minimum inhibitor concentration (MIC): 15.625 µg/mL, H2 MIC: <3.9 µg/mL] against only S. Epidermidis ATCC 49461 strains among the tested microorganisms. Conclusion: In our study, it was determined that two different commercial Hardaliye products contained very low concentrations of phenolic compounds compared to the data in the literature, and therefore it was thought that tested Hardaliye products did not show antioxidant activity.