Bozulmuş Açlık Kan Şekeri ve İnsülin Direnci Olan Hastalarda Çinko ve Bakır Metabolizmasının Araştırılması
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Diabetes mellitus is a worldwide health problem in recent years. Diabetes is a disease that makes long-term defects in lipid, carbohydrate and protein metabolism. Also insulin secretion disorders, insulin resistance and impaired fasting glucose metabolism are important factors that lead individuals to diabetes. The role of zinc and copper trace elements in the etiology of diabetes mellitus (DM) has not been clarified in recent studies. The aim of this research was to investigate the relationship between impaired fasting glucose (IFG) and increased insulin resistance (IR) and trace elements such as Zn and Cu which have important roles in metabolism. There ara four groups which are IFG, Homa-IR, Trype2 DM and control in the study. IFG group consisted of fasting glucose levels according to WHO criteria, IR group was Homa-IR ≥ 2.5, Type2 DM was diagnosed and healthy individuals without IR also fasting glucose level < 100 mg/dL were control group. Control and Type2 DM groups with serum with IFG, IR and control group, Type2DM patients were compared with the control group. Zn and Cu trace element levels were analyzed in all samples. The difference between the groups was calculated using student t-test and the relationship between them was calculated using Pearson Correlation Coefficient. According to the results, there was an extremely significant decrease in Zn level in IFG and Type2 DM groups (p<0.05), while an extremely significant increase in Cu was found in IR group (p<0.05). As a result, it was observed that the changes in Zn and Cu levels were an important factor in the metabolism that predisposes to Type2 DM without separating IR or IFG. Also as a result, it is seen that the incidence of Type2 DM increases with age. It is thought that prediabetes patients should take precautions at early age and period will be an important key to slow down the process leading to diabetes. The low level of zinc and high level of copper in the metabolism of Type2 DM patients indicates that the measures to be taken in prediabetes. In prediabet, Zn supplementation is thought to have an important role in decreasing plasma glucose level and preventing progression to Type2 DM by taking a regulatory role in Zn and Cu levels. Key words: Trace elements, zinc, copper, insulin resistance, impaired fasting glucose, diabetes mellitus.