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Publication Metadata only Real-world treatment outcomes from nationwide Onco-colon Turkey registry in RAS wild-type patients treated with biologics second-line mCRC(2024-04-13) Yildirim M. E.; Karadurmus N.; Okten I. N.; TÜRK H. M.; Urakci Z.; Arslan C.; Celik S.; DANE F.; ŞENDUR M. A. N.; BİLİR C.; et al.; TÜRK, HACI MEHMETBackgrounds and Objectives Colorectal cancer is one of the leading causes of mortality both globally and in our country. In Turkey, we conducted a multicenter investigation into the effectiveness of second-line treatments and real-life data for patients with RAS wild-type metastatic colorectal cancer (NCT04757311).Materials and Methods In this retrospective analysis, records from 28 centers were collected, and histopathological, molecular, and clinical characteristics were documented. Patients were categorized into groups based on their second-line biological treatments: anti-EGFR (Group A and Group B, panitumumab and cetuximab) and anti-VEGF (Group C, bevacizumab and aflibercept). They were then compared within these groups.Results A total of 588 patients with documented RAS wild-type status were evaluated. The median OS was 15.7, 14.3 and 14.7 months in Group A, Group B and Group C, respectively (p = 0.764). The median PFS of the patients in second-line setting that received panitumumab, cetuximab and bevacizumab/aflibercept were 7.8, 6.6 and 7.4 months, respectively (p = 0.848).Conclusion According to the results of our real-life data study, there is no significant difference in efficiency between the combination of biological agent and chemotherapy used in the second-line treatments.Publication Metadata only What is the importance of PROMS on dialysis for kidney healthcare providers?(2024-04-12) Kazancıoğlu R.; Gürsu M.; Elçioğlu Ö. C.; Sayan C.; Yabacı Tak A.; Kurban E.; KAZANCIOĞLU, RÜMEYZA; GÜRSU, MELTEM; ELÇİOĞLU, ÖMER CELAL; YABACI TAK, AYŞEGÜLPublication Metadata only Geriatrik Rehabilitasyonda Sanat Terapi Uygulamalarının Ergoterapi Perspektifiyle İncelenmesi(2024-04-19) Alioğlu D.; Sarışahin S.; Uğurlu Ü.; SARIŞAHİN, SÜMEYYE; UĞURLU, ÜMITGeriatrik Rehabilitasyonda Sanat Terapi Uygulamalarının Ergoterapi Perspektifiyle İncelenmesiYazarlarDerya ALİOĞLU1, Sümeyye SARIŞAHİN2, Ümit UĞURLU3Kurumlar ve İletişim1. Bezmialem Vakıf Üniversitesi, Sağlık Bilimleri Fakültesi, Ergoterapi Bölümü,derya.alioglu@hotmail.com2. Arş. Gör., Bezmialem Vakıf Üniversitesi, Sağlık Bilimleri Fakültesi, Ergoterapi Bölümü,sumeyye.sarisahin@bezmialem.edu.tr3. Prof. Dr., Bezmialem Vakıf Üniversitesi, Sağlık Bilimleri Fakültesi, Ergoterapi Bölümü,uugurlu@bezmialem.edu.trÖZET METNİAMAÇ:Yaşlılık fiziksel, psikolojik ve sosyal boyutları ile değerlendirilmesi gereken bir süreçtir. Bireylerin yaşları ilerledikçe psikomotor yavaşlamanın meydana geldiği bilinmektedir. Araştırma kapsamında yapılan literatür taraması sonucu geriatrik bireylerde ergoterapi müdahalesi kapsamında uygulanan sanat terapisinin kognitif etkisini inceleyen çalışmalara yer verilmiştir.GEREÇ-YÖNTEM:Araştırma yapılırken \"Art Therapy veya Music Therapy veya Dance Therapy\", \"Older People veya Geriatric İndividuals\", \"Occupational Therapy veya Ergotherapy\" ve \"Cognitive\" anahtar kelimeleri kullanılmıştır. Bu kapsamda PubMed, Google Scholar ve OTSeeker veri tabanlarında Boolean arama yöntemiyle aramalar yapılmış olup araştırma kriterlerini sağlayan, 2017-2023 yılları arasında yayınlanmış 7 makale çalışmaya dahil edilmiştir.SONUÇ:Sanat terapi alt türlerinden dans terapi, müzik terapi, drama terapi, el sanatları terapisi ve telerehabilitasyon temelli yaratıcı sanat terapi kullanılan değerlendirme ve müdahale yöntemlerindendir. Geriatrik popülasyonda müdahale programına sıklıkla eşlik eden bir diğer yöntem anımsama terapisidir. Müdahalelerin bilişsel işlevleri iyileştirmede, ilgili popülasyonda depresyonu azaltmada ve danışanların yaşam kalitesini artırmada etkili olduğu bulunmuştur. Ayrıca kişiye özel, anlamlı ve amaçlı okupasyonlara katılımın ilgili popülasyonda davranışsal semptomların yanı sıra bakımveren yükünü ve bakım \"görevi\" için harcanan zamanı azaltabileceği vurgulanmıştır.TARTIŞMA:Okupasyonel katılım sağlıklı yaşlanmanın ayrılmaz bir parçası olarak ifade edilebilir. Yaşlı yetişkinler için sanat terapisi destekli ergoterapi müdahalesi özellikle kognitif beceri gerektiren günlük yaşam aktiviteleri, yardımcı günlük yaşam aktiviteleri, sağlık yönetimi, sosyal katılım, dinlenme ve uyku gibi okupasyonel performans alanlarına katılımı destekler. Uygulanan müdahalelerin bireye özgü olması, süresi, sıklığı ve içeriği müdahalelerin kazanımlarını etkileyebilmektedir. Sanat terapisi destekli ergoterapi müdahalesi sağlık hizmetlerinin bir parçası olarak entegre edilebilir. Geriatrik bireylerin bütüncül ihtiyaçlarını karşılamak için multidisipliner yaklaşımların benimsenmesi önerilmektedir.ANAHTAR KELİMELER:Geriatri, sanat terapisi, kognitif, ergoterapi.Publication Metadata only Evaluation of responses of kidney healthcare providers decision-making processes of end stage kidney disease patients.(2024-04-12) Kazancıoğlu R.; Gürsu M.; Elçioğlu Ö. C.; Sayan C.; Yabacı Tak A.; Kurban E.; KAZANCIOĞLU, RÜMEYZA; GÜRSU, MELTEM; ELÇİOĞLU, ÖMER CELAL; YABACI TAK, AYŞEGÜLPublication Metadata only Is having a moderate or low history, electrocardiogram, age, risk factors, troponin risk score a handicap for long-term mortality?(2024-03-01) Sönmez E.; Taşlıdere B.; Deniz M. A.; Kahraman H.; Özkan A.; Gülen B.; TAŞLIDERE, BAHADIRPublication Metadata only GLUTENSİZ DİYETİN BAZI OTOİMMÜN HASTALIKLARA ETKİSİ(Efe Akademi Yayınları, 2024-06-01) Tayfur B. İ.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEPublication Metadata only Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group.(2024-12-01) Oruc A.; Sumnu A.; Turkmen A.; Basturk T.; Cebeci E.; Turgutalp K.; Cetinkaya H.; Uzerk Kibar M.; Seyahi N.; Tatar E.; et al.; KAZANCIOĞLU, RÜMEYZAPublication Metadata only Post-COVID-19 Outcomes of Patients with Primary Glomerular Diseases: A Nationwide Controlled Study(2024-04-01) Kazancıoğlu R.; KAZANCIOĞLU, RÜMEYZAPublication Open Access The effect of active smoking and secondhand smoke exposure on early outcomes of ambulatory surgery: A prospective observational study(2024-06-01) GÜVEN B.; Sevinç C. K.; Özkaya B. Ö.; Soyhan O.; GÜVEN, BETÜLPurpose: Since the hospital stay of patients after ambulatory surgery is short, it is important to determine the factors that may cause problems in the early postoperative period. Among these factors, the effects of which are not fully known are active smoking and secondhand smoke exposure. This study aimed to elucidate how active smoking and secondhand smoke exposure effect early outcomes of ambulatory surgery. Methods: A prospective observational study was conducted with 124 patients (42 active smokers, 40 nonsmokers exposed to secondhand smoke and 42 nonsmokers) who underwent ambulatory general surgery. Patients were closely monitored for cardiac and respiratory complications, as well as pain, opioid use, and nausea and vomiting until discharge from the hospital. Results: Postoperative complications were observed in 50.8 % of the patients. Hypotension was more common in active smokers compared with nonsmokers and nonsmokers exposed to secondhand smoke. Smokers were more likely to require postoperative supplemental oxygen therapy. Pain intensity at 1st and 4th hours after surgery was significantly higher in smokers (p < 0.005). In addition, nonsmokers exposed to secondhand smoke exhibited more severe pain than nonsmokers (p = 0.001). There were no statistically significant differences between the groups with regard to opioid consumption. Conclusion: Although smoking and secondhand smoke exposure are not associated with serious complications after ambulatory surgery, patients\" comfort and the success of ambulatory surgery may be negatively affected due to severe pain associated with smoking and secondhand smoke exposure.Publication Open Access A new concept for mandible reconstruction after oncological resection: Multisegment virtual surgical planning(2024-01-01) Ismayilzade M.; YILDIZ K.; Canter H. I.; YILDIZ, KEMALETTİNPurpose: Virtual surgical planning (VSP) is good for three dimensional reconstructions in maxillofacial surgery, but it is not problem-free completely especially when the resection margins cannot be affirmed in preoperative period. We aimed to obtain an ideal reconstruction with elaborating VSP to be prepared for adverse conditions during surgery and to proceed the oncological resections step- by- step with A, B, and C resection planes. Patients and methods: Four patients undergoing multisegment VSP for the primary mandible malignancies were included in the study. The first resection margin was detected as plan A in VSP, and plans of B and C were also prepared considering the tumor- positive result of intraoperative frozen section procedure. Results: Following the tumor resection, margins were extended to the plan B in two patients, and plan C in one patient in accordance with the results of the frozen section procedure.Histogram comparison of the localizations of osteotomies in mandible and fibula, and positions of the implants were calculated at a confidence level of 95 % (p > 0.95) and mean difference was found -0.55 mm, while standard deviation was 1.76 mm. Conclusion: Multisegment virtual surgical planning seems to achieve the optimal reconstruction with the staged resection preventing redundant removal of tumor- free structures like bone and teeth.Publication Metadata only Türkiye’de Afet Hemşireliği(nobel akademik yayıncılık, 2023-01-01) ERDOĞAN Ö.; ERDOĞAN, ÖZCANPublication Metadata only DASH Diyetinin Kalp Sağlığı ve Genel Sağlık İçin Önemi(2024-06-01) Bilgin E. N.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEPublication Open Access Receptor for advanced glycation end products polymorphisms in coronary artery ectasia(2024-07-01) Aslan E. I.; Özkara G.; Kilicarslan O.; Ser O. S.; Bostan C.; Yildiz A.; Borekcioglu A. D.; Öztürk O.; Kucukhuseyin O.; Aydogan H. Y.; ÖZKARA, GÜLÇİNBackground: Although the implication of receptor of advanced glycation endproducts (RAGE) has been reported in coronary artery disease, its roles in coronary artery ectasia (CAE) have remained undetermined. Furthermore, the effect of RAGE polymorfisms were not well-defined in scope of soluble RAGE (sRAGE) levels. Thus, we aimed to investigate the influence of the functional polymorphisms of RAGE -374T > A (rs1800624) and G82S (rs2070600) in CAE development. Methods: This prospective observational study was conducted in 2 groups selected of 2452 patients who underwent elective coronary angiography (CAG) for evaluation after positive noninvasive heart tests. Group-I included 98 patients with non-obstructive coronary artery disease and CAE, and Group-II (control) included 100 patients with normal coronary arteries. SNPs were genotyped by real-time PCR using Taqman® genotyping assay. Serum sRAGE and soluble lectin-like oxidized receptor-1 (sOLR1) were assayed by ELISA and serum lipids were measured enzymatically. Results: The frequencies of the RAGE -374A allele and -374AA genotype were significantly higher in CAE patients compared to controls (p < 0.001). sRAGE levels were not different between study groups, while sOLR1 levels were elevated in CAE (p = 0.004). In controls without systemic disease, -374A allele was associated with low sRAGE levels (p < 0.05), but this association was not significant in controls with HT. Similarly, sRAGE levels of CAE patients with both HT and T2DM were higher than those no systemic disease (p = 0.02). The -374A allele was also associated with younger patient age and higher platelet count in the CAE group in both total and subgroup analyses. In the correlation analyses, the -374A allele was also negatively correlated with age and positively correlated with Plt in all of these CAE groups. In the total CAE group, sRAGE levels also showed a positive correlation with age and a negative correlation with HDL-cholesterol levels. On the other hand, a negative correlation was observed between sRAGE and Plt in the total, hypertensive and no systemic disease control subgroups. Multivariate logistic regression analysis confirmed that the -374A allele (p < 0.001), hyperlipidemia (p < 0.05), and high sOLR1 level (p < 0.05) are risk factors for CAE. ROC curve analysis shows that RAGE -374A allele has AUC of 0.713 (sensitivity: 83.7 %, specificity: 59.0 %), which is higher than HLD (sensitivity: 59.2 %, specificity: 69.0 %), HT (sensitivity: 62.4 %, specificity: 61.1 %) and high sOLR1 level (≥0.67 ng/ml)) (sensitivity: 59.8 %, specificity: 58.5 %). Conclusion: Beside the demonstration of the relationship between -374A allele and increased risk of CAE for the first time, our results indicate that antihypertensive and antidiabetic treatment in CAE patients causes an increase in sRAGE levels. The lack of an association between the expected -374A allele and low sRAGE levels in total CAE group was attributed to the high proportion of hypertensive patients and hence to antihypertensive treatment. Moreover, the RAGE -374A allele is associated with younger age at CAE and higher Plt, suggesting that -374A may also be associated with platelet activation, which plays a role in the pathogenesis of CAE. However, our data need to be confirmed in a large study for definitive conclusions.Publication Open Access A new method of pulse control in cardiopulmonary resuscitation; Continuous femoral pulse check.(2024-03-31) Sonmez E.; Taslidere B.; Ozkan A.; TAŞLIDERE, BAHADIRObjectives: The reliability of manual pulse checks has been questioned but is still recommended in cardiopulmonary resuscitation (CPR) guidelines. The aim is to compare the 10-s carotid pulse check (CPC) between heart massage cycles with the continuous femoral pulse check (CoFe PuC) in CPR, and to propose a better location to shorten the interruption times for pulse check. Methods: A prospective study was conducted on 117 Non-traumatic CPR patients between January 2020 and January 2022. A total of 702 dependent pulse measurements were executed, where carotid and femoral pulses were simultaneously assessed. Cardiac ultrasound, end-tidal CO2, saturation, respiration, and blood pressure were employed for pulse validation. Results: The decision time for determining the presence of a pulse in the last cycle of CPR was 3.03 ± 1.26 s for CoFe PuC, significantly shorter than the 10.31 ± 5.24 s for CPC. CoFe PuC predicted the absence of pulse with 74% sensitivity and 88% specificity, while CPC predicted the absence of pulse with 91% sensitivity and 61% specificity. Conclusion: CoFe PuC provides much earlier and more effective information about the pulse than CPC. This shortens the interruption times in CPR. CoFe PuC should be recommended as a new and useful method in CPR guidelines.Publication Metadata only Alzheimer ve Ketojenik Beslenme(Platanus Yayınevi, 2024-06-01) Aksoy S.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEPublication Open Access Video-based exergaming versus conventional rehabilitation on balance in pediatric brain tumor survivors: a randomized clinical trial(2024-06-01) TANRIVERDİ M.; MUTLUAY F.; Çakιr F. B.; TANRIVERDİ, MÜBERRABalance problems are widely reported in Pediatric Brain Tumor Survivors (PBTS) due to tumor localization and the side effects of medical treatment. This study investigates the effects of conventional versus video-based games exercise training (exergaming) on balance in PBTS. The present study was a randomized controlled trial. The study included 23 PBTS who were randomized to a Video-Based balance exergaming Group (VBG) or Conventional balance exercise training Group (CG). In both groups, the interventions were targeted to the balance function and balance exercise training was administered twice a week for 8 weeks. VBG exercised using selected Nintendo Wii Fit Plus® balance games while CG received a specially designed balance training using conventional physiotherapy methods. The primary outcome was the balance tests (Timed Up and Go and Nintendo® Wii™ Center of Gravity: COG), and the secondary outcomes were the functional tests (10-m walking, 2-min walking, 5-step climb/descent/times), and disease effect test (PedsQL Brain Tumor Module). The outcomes were assessed before and after the intervention. At baseline, no significant clinical and outcome assessment differences existed between both groups except for COG (p = 0.0495). After training, overall scores for balance, functional, disease effect tests significantly improved in VBG (p 0.05). Video-based balance exergaming was found effective and more so than conventional balance exercise training in PBTS. Greater effectiveness of exergaming is thought to be due to increased motivation and effort of the children who are more attracted to gaming than conventional exercising. Exergaming could be beneficial both in clinical and home settings with physiotherapist supervision and may reduce the costs of treatment while improving their health-related quality of life.Publication Metadata only Reliability and Validity of the Turkish Translation of the PedsQL™ 3.0 Neuromuscular Module for 2-to 4-Year-Olds in Spinal Muscular Atrophy.(2024-04-08) Kutlutürk Yikilmaz S.; TANRIVERDİ M.; OKTEM S.; TANRIVERDİ, MÜBERRABackground: The Pediatric Quality of Life InventoryTM Neuromuscular Module (PedsQLTM 3.0 NM) evaluates the health-related quality of life in children who are affected by neuromuscular diseases. This study’s aim is to assess the adaptation of the PedsQLTM 3.0 NM Turkish version (PedsQLTM 3.0 NM-TR) for 2-4 years old in spinal muscular atrophy (SMA). Methods: The procedure of translating the PedsQLTM 3.0 NM into Turkish was conducted in accordance with the translation methodology outlined by the PedsQLTM measurement model. The PedsQLTM 3.0 NM-TR was administered to 54 parents of children with SMA aged 2-4 years. The test-retest reliability and intraclass correlation coefficient (ICC) were measured for reliability analysis. Cronbach\"s alpha coefficient and item score correlations were calculated for internal consistency. Concurrent construct validity was evaluated by Pearson correlations between the outcomes of the PedsQLTM 4.0 Generic Core Scale (PedsQLTM 4.0 GCS) and the PedsQLTM 3.0 NM. Results: The PedsQLTM 3.0 NM-TR total score shows excellent reliability. The Cronbach\"s alpha values for the PedsQLTM 3.0 NM ranged between 0.871-0.906, while those for the PedsQLTM 4.0 GCS ranged 0.843-0.897. Test-retest ICC values for the PedsQLTM 3.0 NM-TR ranged 0.812-0.917, and for the PedsQLTM 4.0 GCS ranged 0.773-0.899. The relationship between the PedsQLTM 3.0 NM-TR and the subscores of the PedsQLTM 4.0 GCS demonstrated a range of correlations from excellent to fair, indicating the interplay between two scales. Conclusions: This study established the PedsQLTM 3.0 NM-TR as reliable, valid, and feasible for use in children aged 2-4 years old with SMA.Publication Metadata only Baş Boyun Kanseri Sonrası Disfaji: Yutma Rehabilitasyonunun İki Olgu Üzerindeki Etkisi(2024-03-24) Öztoprak N.; Tanrıverdi M.; Törpü G. C.; TANRIVERDİ, MÜBERRAPublication Metadata only Capacity for the management of kidney failure in the International Society of Nephrology Eastern and Central Europe region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)(2024-04-01) Alparslan C.; Malyszko J.; Caskey F. J.; Aleckovic-Halilovic M.; Hrušková Z.; Arruebo S.; Bello A. K.; Damster S.; Donner J.; Jha V.; et al.; KAZANCIOĞLU, RÜMEYZADelivery of care for kidney failure (KF) globally has a significant disparity; even in some countries, it means end of life for the person. The International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) tries to address gaps in KF care and standardize global nephrology care. From the third iteration of the ISN-GKHA, we present data for countries in the ISN Eastern and Central Europe region. The median prevalences of chronic kidney disease (12.8%) and treated KF (873.5 pmp) were higher than the global rates, respectively. Hemodialysis was the most preferred modality for KF in adults, whereas kidney replacement therapy was more balanced in children. Although most of the countries in the region had lower-middle–income and upper-middle–income levels, health expenditures for kidney health care were almost generally covered publicly. Nephrologists were responsible for the medical kidney care of people with KF in all countries. There was adequate infrastructure to provide all kinds of treatment for kidney care in the region. Regional characteristics such as high levels of obesity, smoking, and Balkan nephropathy as an endemic disease coupled with a shortage of workforce and finance continued to affect kidney care in the region negatively. By making organizational and legislative arrangements, partnerships with national authorities and societies may accelerate the improvement of kidney health care in the region.Publication Metadata only Peritoneal dialysis drop out causes- a single center retrospective study.(2024-04-12) Shehaj L.; Gürsu M.; Elçioğlu Ö. C.; Kazancıoğlu R.; Sayan C.; GÜRSU, MELTEM; ELÇİOĞLU, ÖMER CELAL; KAZANCIOĞLU, RÜMEYZA