Yayınlar - Eserler
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12645/130
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Publication Metadata only Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells(2024-01-01) Kaymak S.; Kurtur O. B.; Gok B.; KILINÇ Y.; Kecel-Gunduz S.; Nath E. Ö.; KARTAL M.Introduction: Osteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low-toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic. Objective: In this study, we aim to prepare a controlled drug carrier system loaded with Gypsophila eriocalyx to determine its potential for anti-osteoporosis applications. Methods: Gypsophila eriocalyx extract (GEE) was prepared, and components were determined. The molecular interactions of the components with Cathepsin K (CatK), which is used as a target in drug development against osteoporosis, were revealed by in silico molecular docking and MD methods. ADMET profiles were also examined. GEE-loaded chitosan nanoparticles (CNPs) were synthesized. The nanoparticles\" morphology, encapsulation efficiency, loading capacity, release profile, average size, polydispersity index, and zeta potentials were determined. The cytotoxic effects of GEE and GEE-loaded CNPs on the L929 and osteogenic proliferation profiles on human bone marrow stem cells (hBMC) were examined. Results: The MD analysis revealed no breaks or atomic changes in the dynamic system, and the docking analysis confirmed the continued interaction of identical residues. It was determined that the GEE-loaded CNP formulation was produced successfully, had no toxic effect on the L929, and had an osteogenic proliferation effect on hBMC. Conclusion: In line with the in vitro and in silico results obtained, it was evaluated that GEE-loaded CNPs can be used as a controlled drug release system as a candidate formulation with phytotherapeutic properties for osteoporosis treatment.q1.Publication Metadata only Prevalence, distribution, and prognostic significance of morphological variants of neuroendocrine tumors of the gastrointestinal tract - a multicenter study(2024-01-01) Akay E.; Ordu M.; ÇOBAN G.; Darakcı S.; Topaloğlu N.; Taştekin F. M.; Ekinci B.; ŞAHİN N.; GÜCİN Z.; Karaman H.The incidence and prevalence of neuroendocrine neoplasms (NENs) in many organs are increasing. Although such NENs have similar grades, they may exhibit quite different behaviors. In this multicenter study, we aimed to investigate the prevalence and distribution of different morphological NEN variants in the non-pancreatic gastrointestinal (GI) tract and determine whether they can guide prognosis prediction. Two hundred and fifty-six patients diagnosed with NENs originating from the GI tract from 7 different centers were included in the study. In 89 (36.6%) cases, different morphological variants were detected. When the variants were grouped according to their aggressiveness as described in the literature, a statistically significant relationship between aggressiveness and the variables organ and age was found ( p < 0.05). The oncocytic variant was found to metastasize more than the other aggressive types (42.9%). The paraganglioma-like variant was found to have a smaller size, lower proliferation index, and a more benign clinical course. This study demonstrated that well-differentiated GI neuroendocrine tumors (GI-NETs) have considerable morphological diversity. Generally, case reports of rare morphological variants of GI-NETs are available in the literature. We believe that our study contributes to a better understanding of the prevalence, localization, and significance of morphological variations in GI-NETs.Publication Metadata only Association between celiac disease and fibromyalgia and their severity: a cross-sectional study.(2024-08-30) Kılıçoğlu M. S.; Sayılır S.; Yurdakul O. V.; Aydin T.; Koçhan K.; Basaranoglu M.; Kucukakkas O.Publication Metadata only Risk Factors for Depression in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.(2024-09-04) Liu J.; Jin H.; Yon D. K.; Soysal P.; Koyanagi A.; Smith L.; Shin J. I.; Li Y.; Rahmati M.; Zhang J.Publication Metadata only Papillomavirus infection and male infertility: A systematic review and meta-analysis.(2024-08-29) Garolla A.; Mereu S.; Pizzol D.; Yon D. K.; Rahmati M.; Soysal P.; Ilie P. C.; Bertoldo A.; Trott M.; Smith L.Publication Metadata only Food insecurity and body mass index among older people: A systematic review and meta-analysis.(2024-08-27) Gianfredi V.; Nucci D.; Lattanzio R.; Piccinelli S.; Cicconi G.; Farfan S. J. S.; Berti A.; D'Amico M.; Sabatelli N.; Guzzardi F.; et al.Publication Metadata only Global burden of vaccine-associated rheumatic diseases and their related vaccines, 1967–2023: A comprehensive analysis of the international pharmacovigilance database(2024-08-01) Oh J.; Jo H.; Park J.; Lee H.; Kim H. J.; Lee H.; Kang J.; Hwang J.; Woo S.; Son Y.; et al.Vaccine-associated rheumatic diseases are rare but one of the most feared adverse drug reactions (ADRs). However, this topic has been investigated less with large-scale data in the literature. With the rapid progress in the development and approval of vaccines during the pandemic, public concerns regarding their safety have been raised. To assess the global and regional burden, long-term trends, and potential risk factors of vaccines-associated six types of rheumatic diseases (ankylosing spondylitis [AS], polymyalgia rheumatica [PMR], rheumatoid arthritis [RA], Sjögren\"s syndrome, Systemic lupus erythematosus [SLE], Systemic scleroderma), this study conducted disproportionality analysis based on the reports from the World Health Organization International Pharmacovigilance Database documented between 1967 and 2023 (n for total reports = 131 255 418) across 156 countries and territories. We estimated the reporting odds ratio (ROR) and information component (IC) to determine the disproportionality signal for rheumatic diseases. Of 198 046 reports of all-cause rheumatic diseases, 14 703 reports of vaccine-associated rheumatic diseases were identified. While the reporting counts have gradually increased over time globally, we observed a dramatic increase in reporting counts after 2020, potentially due to a large portion of reports of COVID-19 mRNA vaccine-associated rheumatic diseases. The disproportionality signal for rheumatic diseases was most pronounced in HBV vaccines (ROR, 4.11; IC025, 1.90), followed by COVID-19 mRNA (ROR, 2.79; IC025, 1.25), anthrax (ROR, 2.52; IC025, 0.76), papillomavirus (ROR, 2.16; IC025, 0.95), encephalitis (ROR, 2.01; IC025, 0.58), typhoid (ROR, 1.91; IC025, 0.44), influenza (ROR, 1.49; IC025, 0.46), and HAV vaccines (ROR, 1.41; IC025, 0.20). From age- and sex-specific perspective, young females and old males are likely to have vaccine-associated rheumatic disease reports. Furthermore, overall vaccines showed a disproportionality signal for PMR (IC025, 3.13) and Sjögren\"s syndrome (IC025, 0.70), systemic scleroderma (IC025, 0.64), specifically while the COVID-19 mRNA vaccines are associated with all six types of diseases. Although multiple vaccines are associated with rheumatic disease reports, healthcare providers should be aware of the potential of autoimmune manifestations following vaccination, particularly the COVID-19 mRNA and HBV vaccines, and take into account for risk factors associated with these ADRs. Most ADRs exhibited an average time to onset of 11 days, underscoring the significance of monitoring and timely management by clinicians.Publication Metadata only Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study(2024-08-01) Korkmaz N. D.; Elibol B.; Süsgün S.; Toruntay C.; Bayrakoğlu A.; Yüzgüleç M.; Elagöz Z.; Yabacı Tak A.; Yücesan E.; Uslu F.; et al.,ABSTRACT Objective: Neuroinflammation and blood-brain barrier (BBB) dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimer\"s Disease (AD), Parkinson\"s Disease (PD), Multiple Sclerosis (MS), and epilepsy. Materials and Methods: We measured levels of lipopolysaccharide (LPS), the largest endotoxin, and brain-derived neurotrophic factor (BDNF) in patients\" blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases. Results: Significant associations were observed between LPS, C-reactive protein (CRP), BDNF, and lactate dehydrogenase (LDH) levels across conditions. LPS was positively correlated with CRP levels in epilepsy (r=0.753, p=0.002). Additionally, BDNF was negatively correlated with CRP in PD patients (r=-0.53, p=0.042). Moreover, a negative correlation was found between LPS and LDH in AD patients (r=-0.521, p=0.047). Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies. Keywords: Brain-derived neurotrophic factor, lipopolysaccharide, neuroinflammation, neurological diseases, biomarkerPublication Metadata only Effect of Hospital Employees’ Psychological Capital on Counterproductive Work Behavior: Role of Work Alienation and Procrastination(2024-08-01) Ayşe Göksu Özüdoğru G.; Görener A.; Toker K.Counterproductive work behavior (CWB) causes financial losses and psychologically affects other employees exposed to verbal or physical attacks from their colleagues. This issue creates a stressful workplace and has a negative impact on organizational outputs. The objective of this study is to develop a coherent logic and a thorough comprehension of the CWB’s predecessors and their relationships to the CWB. Our research applied partial least squares structural equation modeling (PLS-SEM) to test hypotheses on a sample of 390 healthcare personnel in a hospital. We propose an approach in which administrators can reduce counterproductive work behaviors by strengthening psychological capital. Also, eliminating work alienation and workplace procrastination is an original and critical argument for preventing counterproductive work behavior. The findings reveal that high psychological capital negatively affected counterproductive work behaviors and reduced these behaviors in the workplace. However, the partial mediation role of work alienation and the mediation role of workplace procrastination were determined in the relationship between psychological capital and counterproductive work behaviorPublication Metadata only Fritillaria imperialis L. ve Fritillaria pinardii Boiss. Türlerinin Antimikrobiyal Aktiviteleri(2023-12-07) Esen O.; Doğanay D.; Alim Toraman G. Ö.; Aydın M.; Topçu G.Publication Metadata only 4. Bölüm: Retiküler Sistem(Akademisyen Yayınevi Kitabevi, 2024-03-01) Arifoğlu Y.Publication Metadata only Nöral Foramen ve İntervertebral Diskin Morfolojik Özelliklerinin Transforaminal Epidural Steroid Enjeksiyonunun Başarısına Etkisi: Gözlemsel Bir Çalışma(2023-06-01) Öztürk E. C.; Zeren E.; Şehirli Ü. S.; Arifoğlu Y.; Şencan S.; Gündüz O. H.Publication Metadata only Tibialis spastic varus foot without tarsal coalition: a case report(2024-08-19) İNCESOY M. A.; UZER G.Tibialis spastic varus foot (TSVF) is an uncommon clinical entity primarily associated with tarsal coalition. This case report presents a rare instance of TSVF without tarsal coalition in an 8-year-old male patient. Successful treatment was achieved through a conservative approach involving botulinum toxin injections and a plaster cast, highlighting the potential of nonsurgical interventions for this rare condition. ,,Tibialis spastic varus foot\" (TSVF) ohne tarsale Koalition ist eine seltene klinische Entit & auml;t, die in erster Linie mit einer tarsalen Koalition einhergeht. In diesem Fallbericht wird ein seltener Fall von TSVF ohne tarsale Koalition bei einem 8-j & auml;hrigen m & auml;nnlichen Patienten vorgestellt. Die erfolgreiche Behandlung wurde durch einen konservativen Ansatz mit Botulinumtoxin-Injektionen und einem Gipsverband erreicht, was das Potenzial nichtchirurgischer Eingriffe bei dieser seltenen Erkrankung unterstreicht.Publication Metadata only Phenyldiazenyl-phenoxy-1,2,3-triazol-acetamide derivatives as new dual cholinesterase Inhibitors: design, synthesis, in vitro, and in silico enzymatic inhibition evaluations(2025-02-01) Zareei S.; Mohammadi-Khanaposhtani M.; Shahali M.; Şenol H.; Badbedast M.; Moazzam A.; Mohseni S.; Esfahani E. N.; Ekti S. F.; Larijani B.; et al.Publication Metadata only 1-Benzhydryl-piperazine: Isolation, structure determination, and in silico studies for a novel potential narcotic agent detected in sports supplements(2024-11-01) Arslan Z.; Okuroğlu E.; Şenol H.; Türkmen Z.Publication Metadata only Auditory system and COVID-19(2024-07-01) Başöz M.; Taş N.Publication Metadata only Impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients with acute gastrointestinal bleeding: an international multicenter study(2024-08-12) Yin Y.; Ji F.; Romeiro F. G.; Sun M.; Zhu Q.; Ma D.; Yuan S.; He Y.; Liu X.; Philips C. A.; et al.Objectives: Peptic ulcer is the most common source of non-variceal bleeding. However, it remains controversial whether the outcomes of cirrhotic patients with peptic ulcer bleeding differ from those with variceal bleeding. Methods: Cirrhotic patients with acute gastrointestinal bleeding (AGIB) who underwent endoscopy and had an identifiable source of bleeding were retrospectively screened from an international multicenter cohort. Logistic regression analyses were performed to explore the impact of peptic ulcer bleeding on in-hospital death and 5-day failure to control bleeding. Propensity score matching (PSM) analysis was performed by matching age, gender, Child-Pugh score, and model for end-stage liver disease score between the peptic ulcer bleeding and variceal bleeding groups. Results: Overall, 1535 patients were included, of whom 73 (4.7%) had peptic ulcer bleeding. Multivariate logistic regression analyses showed that peptic ulcer bleeding was not independently associated with in-hospital death (OR = 2.169, p = 0.126) or 5-day failure to control bleeding (OR = 1.230, p = 0.680). PSM analyses demonstrated that both in-hospital mortality (9.7% vs. 6.3%, p = 0.376) and rate of 5-day failure to control bleeding (6.9% vs. 5.4%, p = 0.787) were not significantly different between the two groups. Conclusions: The impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients is similar to that of variceal bleeding.Publication Metadata only The results of adding immunotherapy to chemotherapy in patients with small cell lung cancer: Registurk-Lung study-Real-world data(2024-06-01) Cil T.; Hacibekiroglu I.; Uncu D.; Isikdogan A.; Ates O.; Sendur M. A. N.; Bilici M.; Geredeli C.; Turk H. M.; Cicin I.; et al.Publication Metadata only Auditory system and COVID-19(2024-08-01) Başöz M.; Tas Elibol N.The COVID-19 pandemic that emerged in 2020 may affect the peripheral and central auditory system. According to studies in the literature, symptoms affecting the vestibulocochlear system such as sudden hearing loss, tinnitus, and vestibular neuritis are seen in individuals with COVID -19. While viral pathogens directly affect the structures that supply blood and nutrition to the inner ear, such as the stria vascularis, they can indirectly cause hearing disorders by damaging the immune system. Depending on the affected anatomical region, different symptoms can be observed in individuals. For this reason, post-disease audiological evaluations should be made for individuals with COVID-19. Annual follow-up of these individuals should be added to clinical procedures so that long-acting effects are not overlooked.Publication Metadata only Prognostic factors and validation of the histologic chronicity score for C3 glomerulopathy: a registry analysis(2024-08-01) MİRİOĞLU Ş.; Cebeci E.; Yazici H.; DERİCİ Ü.; Sahin G.; ÇOBAN G.; EREN N.; Gungor O.; Dede F.; DİNÇER M. T.; et al.Background Data on the prognostic factors for C3 glomerulopathy (C3G) are limited, and validation of the new C3G histologic index (C3G-HI) in different settings is still needed. We aimed to evaluate the chronicity score of C3G-HI and probable prognostic factors in our population. Methods In this registry study, 74 patients from 20 centers with adequate follow-up data were included. Total chronicity score (TCS) was calculated according to percentages of glomerulosclerosis, interstitial fibrosis, tubular atrophy, and presence of arterio- and arteriolosclerosis. Primary composite outcome was defined as doubling of serum creatinine from baseline, undergoing dialysis or transplantation, development of stage 5 chronic kidney disease, or death. Results Median age was 34 [interquartile range (IQR) 24-46] years, and 39 patients (52.7%) were male. Median follow-up duration was 36 (IQR 12-60) months, and median TCS was 3 (IQR 1-5). Overall, 19 patients (25.7%) experienced primary composite outcome. Multivariate Cox regression model showed that only hemoglobin [adjusted HR (aHR) 0.67, 95% confidence interval 0.46-0.97, P = .035] predicted primary composite outcome, and TCS fell short of the statistical significance (aHR 1.26, 0.97-1.64, P = .08). Receiver operating characteristic analysis demonstrated that TCS showed an area under the curve value of 0.68 (0.56-0.78, P = .028) in discriminating primary composite outcome at 3 years, and 3-year kidney survival was lower in patients with TCS >= 4 (72.4%) compared with TCS = 4 was associated with a worse 3-year kidney survival, which validated the 3-year prognostic value of the TCS of C3G-HI in our population.