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    Role of cell-free DNA and extracellular vesicles for diagnosis and surveillance in patients with glioma
    (2024-01-01) Karaçam B.; Elbasan E. B.; Khan I.; Akdur K.; Mahfooz S.; Merve C.; Yusuf C.; Hatiboğlu M. A.; KARAÇAM, BÜŞRA; HATİBOĞLU, MUSTAFA AZİZ
    Objectives: Liquid biopsy can be used to make the diagnosis, to screen treatment response, and to predict the prognosis. Extracellular vesicles (EVs) and cell-free DNA (cfDNA) sources are used as liquid biopsy biomarkers from body fluids such as serum, cerebrospinal fluid, urine, and mucosa. The purpose of this study was to investigate whether EVs and cfDNA are predictive for diagnosis and prognosis in patients with glioma. Methods: cfDNA and EVs levels were measured from 17 glioma patients at three different time intervals (before surgery, 10–14 days after surgery, and at the time of recurrence) and 7 healthy individuals. We investigated whether their level increased in glioma patients. Also, the correlation between clinical outcome and their levels was analyzed. Results: The mean serum cfDNA level in glioma patients was found to be higher compared to that in healthy controls. The difference between cfDNA level before surgery and that at 3 months follow-up was found to be statistically significant. Also, the mean serum EVs level in the glioma patients was found to be significantly higher compared to that in the control group. Discussion: Our results suggested that cfDNA and EVs could be used as diagnostic biomarkers in patients with glioma. cfDNA could be also a possible biomarker for the surveillance of glioma patients. Further studies are warranted to confirm our findings
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    Sleep Hygiene Education in Adolescents: The Role of the Pediatric Nurses
    (2024-02-01) Koyuncuoğlu E.; Gözen D.; KOYUNCUOĞLU, ELİF
    Pediatric nurses have an essential role in promoting adolescent health. Adolescence is a vital childhood period. This period is the transition from childhood to adulthood, and the mainstay of a healthy life occurs. Adolescents’ needs and risks should be considered to continue their growth and development. Sleep is an essential factor influencing adolescent health, such as nutrition, physical activity, psychosocial environment, and risky behaviors. Sleep is directly related to situations such as physical health, the development of cognitive skills, and risky behaviors for adolescents. If adolescents do not have adequate and quality sleep, they face various problems such as learning difficulties, low academic success, accidents, and injuries. Sleep hygiene programs are beneficial for preventing adolescent’s sleep problems. Sleep hygiene programs contain parameters such as creating a sleep schedule, regulating daily physical activity and eating habits, creating a pre-sleep routine, reducing caffeine consumption, and creating a sleep environment. Pediatric nurses lead sleep hygiene education programs together with adolescents’ parents, teachers, and healthcare professionals. It is recommended to develop games and web-based alternative designs. Games and web-based designs increase the effectiveness of sleep hygiene programs. This article aimed to emphasize the importance of sleep health in adolescents and the roles of pediatric nurses. Sleep hygiene practices are essential to develop healthy sleep patterns in adolescents. The article points out the roles of pediatric nurses, such as educators, guides, and consultants, in promoting the sleep health of adolescents. Keywords: Adolescent, sleep hygiene education, pediatric nursing.
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    Ketojenik Diyetin Sporcular Üzerine Etkisi
    (Vize Yayıncılık, 2024-02-01) Mendeş B.; MENDEŞ, BEYZA
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    Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model
    (2024-02-01) Aydin B.; Sagiroglu A.; Öztürk Civelek D.; Gokce M.; Bahadori F.; ÖZTÜRK CİVELEK, DİLEK
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    Miyofasyal Gevşetme Teknikleri
    (İstanbul Tıp Kitabevi, 2024-01-01) ÇINAR B.; TUNCER D.; ÇINAR, BETÜL; TUNCER, DENİZ
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    Skolyoz Teknikleri
    (İstanbul Kit (Fatih), 2024-02-01) Manzak A. S.; Yıldırım S.; MANZAK, AYŞE SENA; YILDIRIM, SEFA
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    Üst Çene Ön Dişlerin Dijital Görüntülerinde Yapılan Değişikliklerin Diş Hekimliği Öğrencileri ve Meslek Dışı Bireylerin Estetik Algısına Etkisi: Anket Çalışması: Kesitsel Araştırma
    (2023-12-01) Özduman Z. C.; Acar N.; Uçak G.; Değer C.; ÖZDUMAN, ZÜMRÜT CEREN; DEĞER, CEREN
    Amaç:Bu araştırmanın amacı, üst santral dişlerde insizal embraşür, kron boyutu ve orta hat diastema miktarındaki değişikliklerin, meslek dışı bireyler; diş hekimliği 2 ve 3. sınıf (preklinik) öğrencileri ve diş hekimliği 4 ve 5. sınıf (klinik) öğrencileri arasında estetik algıya olan etkisini değerlendirmektir.Gereç ve Yöntemler:Gülümseme bileşenleri açısından estetik gülümsemeye sahip, kadın bireyden gülümseme fotoğrafı alınmıştır. Ana fotoğraf referans olarak kullanılmıştır ve diğer 10 görüntü, Adobe Photoshop CC 2018 programı kullanılarak gülümseme bileşenlerinde modifikasyonlar yapılarak oluşturulmuştur. Değişiklik yapılan gülümseme bileşenleri; üst santral dişlerde insizal embraşür, kron boyutu ve orta hat diastemasıdır. Her görüntüde bir değişende modifikasyon yapılmıştır. Anket formu, cinsiyet ve diş hekimliği öğrencilerinin sınıf bilgisinin yer aldığı tanımlayıcı sorular içermektedir. Referans görüntü ve modifiye edilmiş 10 adet gülümseme ile birlikte toplam 11 adet görüntü kullanılmıştır. Her bir görüntü için ayrı, 0-10 değerleri arasında bir skala, formlara eklenmiş ve gönüllü katılımcılardan estetik açıdan değerlendirme yapmaları istenmiştir. İnternet ortamında hazırlanan ankete 232 meslek dışı birey, 175 preklinik öğrencisi ve 183 klinik öğrencisi katılmıştır. Görüntülerin estetik algısı skorlarının karşılaştırılmasında \"bağımsız t-testi\" ve \"tek yönlü varyans analizi\" yapılmıştır. Farklı grupları belirlemede \"Duncan testi\" kullanılmıştır.Bulgular:Orta hat diasteması 3 mm bulunan görüntü hem preklinik hem de klinik öğrenci grubu tarafından en düşük skoru alan görüntüdür (p<0,05). Yalnızca 2 mm santral boyu kısaltma yapılan görüntüde, preklinik öğrencileri ile klinik öğrencilerinin estetik algısı açısından anlamlı bir fark ortaya çıkmıştır (p<0,05). Görüntüler arası yapılan karşılaştırma sonuçlarında istatistiksel olarak anlamlı farklılıklar gözlenmiştir (p<0,05).Sonuç:Çalışmada 2 mm santral boyu kısaltma yapılan görüntü dışındaki tüm görüntülerde preklinik öğrenciler ve klinik öğrencilerin görüntülere verdiği estetik skorlar benzerdir.
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    Simultaneous analysis of sacubitril and valsartan by novel analytical methods with green approach
    (2024-04-01) TIRIS G.; Ayse Genc A.; ERK N.; TIRIS, GİZEM
    A novel high performance liquid chromatography (HPLC) and spectrophotometric analysis were applied for quantification of active substances of sacubitril (SAC) and valsartan (VAL). HPLC experiments were conducted on the Waters Spherisorb® (3.0 µm 60.0x4.0 mm) column. Preparation of mobile phase A: 200 mL of 0.1 % solution of trifluoroacetic acid in water and 800 mL of 0.1 % solution of trifluoroacetic acid in acetonitrile by volume are mixed. Preparation of mobile phase B: 800 mL of a 0.1 % solution of trifluoroacetic acid in water and 200 mL of 0.1 % solution of trifluoroacetic acid in acetonitrile by volume were mixed. It was given to the system at the ratio of Mobile Phase A: Mobile Phase B (35:65 v:v). The specimen was injected into the column at 15.0 µL. A detection wavelength of 254.0 nm was preferred for the compound and the flow rate was 2.0 mL/min. Analysis was completed in 4.0 min. The column oven temperature was adjusted to 40.0 °C. The methods were evaluated in terms of green chemistry. The methods have been validated according to ICH guidelines. For HPLC method calibration graphs were constructed in the 20.0– 145.0 and 20.0 – 155 µg/mL SAC and VAL respectively with an R2 of 1.000. In recovery experiments, the RSD values were calculated to be 0.08 % and 0.34 % for SAC and VAL, respectively. Additionally, in intraday and interday experiments, percent RSD values were found to be between 0.23 and 0.49. The method developed for the analysis of the active substances has been developed with a short analysis time and is cost effective. SAC and VAL were determined using a novel method for spectrophotometric analysis. The determination was performed simultaneously using the applied method. This method is a constant center method. Calibration graphs were constructed in the 2.0– 20.0 and 2.0 – 25 µg/mL SAC and VAL with an R2 of 0.9998 and 0.9999 respectively. It is a greenness method in terms of the analysis time and solvent used.
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    Phenylketonuria Disease and Its Managment in Different Individuals
    (2024-03-01) Gül E.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE
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    Treatment With an Interatrial Shunt in Heart Failure: 1-Year Outcomes of the PRELIEVE Study
    (2024-03-01) Paitazoglou C.; Bergmann M. W.; Kilicaslan B.; KILIÇ T.; Bartunek J.; Pfister R.; Iliadis C.; KAYA E. B.; ÖZDEMİR R.; ÖZDEMİR, RAMAZAN
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    An incidental diagnosis of an unusually located echinococcus alveolaris.
    (2023-11-09) Çoban G.; Abdallah A.; Gücin Z.; Alkan A.; ALKAN, ALPAY
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    Promising outcome of patients with recurrent glioblastoma after Gamma Knife-based hypofractionated radiotherapy
    (2024-03-01) HATİBOĞLU M. A.; Akdur K.; Sakarcan A.; SEYİTHANOĞLU M. H.; TÜRK H. M.; Sinclair G.; ÖZTANIR M. N.; HATİBOĞLU, MUSTAFA AZİZ; SEYİTHANOĞLU, MEHMET HAKAN; TÜRK, HACI MEHMET; ÖZTANIR, MUSTAFA NAMIK
    Background: The role of Gamma Knife radiosurgery (GKRS) in recurrent glioblastoma remains unclear. The purpose of this study is to evaluate the effects of GKRS in a group of patients with recurrent glioblastoma, focusing on survival and safety. Methods: Patients undergoing GKRS for recurrent glioblastoma between September 2014 and April 2019 were included in this study. Relevant clinical and radiosurgical data, including GKRS-related complications, were recorded and analyzed. Overall survival (OS), local progression free survival (LPFS) and prognostic factors for outcome were thoroughly evaluated. Results: Fifty-three patients were analyzed (24 female, 29 male). The median age was 50 years (range, 19–78 years). The median GKRS treatment volume was 35.01 cm3 (range, 2.38-115.57 cm3). Twenty patients (38%) were treated with single fraction GKRS, while 33 (62%) were treated with GKRS-based hypofractionated stereotactic radiotherapy (HSRT). The median prescription dose for single fraction GKRS, 3-fractions HSRT and 5-fractions HSRT were 16 Gy (range, 10−20 Gy), 27 Gy (range, 18−33 Gy) and 25 Gy (range, 25−30 Gy), respectively. The median LPFS and OS times were 8.1 months and 11.4 months after GKRS, respectively. HSRT and Bevacizumab were associated with improved LPFS, while HSRT alone was associated with longer OS. Conclusion: Our findings suggested that HRST would likely improve LPFS and OS in definite settings; the addition of Bevacizumab to GKRS was associated with increased rates of local control. No major complications were reported. Further prospective studies are warranted to confirm our findings.
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    HAŞİMATO HASTALIĞINDA BESLENME YAKLAŞIMLARI
    (2024-02-25) Sungur C.; Mendeş B.; MENDEŞ, BEYZA
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    Medikal Estetik Pratik Yaklaşımlar
    (Ema Tıp Kitabevi Yayıncılık Tic. Ltd.Şti., 2024-02-01) Meydan S. (Editör); Mustafayev N. (Editör); MEYDAN, SEDAT
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    CURCUMIN AND METABOLIC SYNDROME RELATIONSHIP
    (2024-02-19) Bayrakdar S.; Mendeş B.; MENDEŞ, BEYZA
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    Conjunctival and nasal microflora in patients on topical cyclosporine for dry eye
    (2024-01-01) Elibol E. S.; Habip Z.; ELBAY A.; Cırık A. A.; Oğuz H.; ELBAY, AHMET
    Introduction: Dry eye is a common ocular condition causing discomfort and visual disturbances. Anti-inflammatory agents like Cyclosporine A (CsA) are often used in its treatment. However, the impact of CsA on ocular flora remains understudied. This research aimed to evaluate changes in conjunctival and nasal microflora in patients receiving topical cyclosporine for dry eye. Methods: In this cross-sectional study, conjunctival and nasal samples were collected from two groups of dry eye patients. Group 1 consisted of 38 patients using CsA eye drops, while Group 2 included 34 patients using preservative-free artificial tear drops. Bacterial cultures were grown from the samples, and the identified organisms underwent antibiotic susceptibility testing. Additionally, alpha diversity metrics were employed to assess the diversity of bacterial species in the samples. Results: Bacterial growth was observed in 75% of conjunctival samples and 97.22% of nasal samples. Staphylococcus epidermidis was the predominant organism in both groups. Alpha diversity analysis showed no significant differences in Shannon diversity and OTU richness between the groups for most bacterial species. Antibiotic susceptibility tests revealed no substantial variations in resistance patterns between the groups. Conclusion: This study provides valuable insights into the impact of CsA eye drops on conjunctival and nasal flora in dry eye patients. The findings suggest that CsA does not significantly influence the composition, diversity, or antibiotic resistance patterns of ocular flora. Long-term topical cyclosporine treatment for dry eye does not significantly impact conjunctival microflora or lead to antibiotic resistance. These results have important implications for the safe use of CsA in patients undergoing ocular treatments, particularly those at risk of intraocular infections.
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    MEDICAL NUTRITION THERAPY OF CYSTIC FIBROSIS – ASSOCIATED DIABETES
    (2024-02-19) Aytulu Ş.; Mendeş B.; MENDEŞ, BEYZA