Comparison of Cockcroft-Gault and Modification of Diet in Renal Disease Formulas as Predictors of Cardiovascular Outcomes in Patients With Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention
Date
2014-10-01Author
Orhan, AhmetCekirdekci, Elif Iclal
Ozcan, Kazim Serhan
Erer, Hatice Betul
Osmanov, Damir
Eren, Mehmet
Sayar, Nurten
Cicek, Gokhan
Bozbay, Mehmet
Ekmekci, Ahmet
Uluganyan, MAHMUT
Gungor, Baris
Tufan, Fatih
Advisor
Type
Metadata
Show full item recordAbstract
We prospectively assessed the value of estimated glomerular filtration rate (eGFR) by the Modification of Diet in Renal Disease
(MDRD) and Cockcroft-Gault (C-G) equations in predicting inhospital adverse outcomes after primary coronary intervention for
acute ST-segment elevation myocardial infarction. We classified 647 patients into 3 categories according to eGFR, <60, 60 to 90,
and >90 mL/min/1.73 m2
. The eGFRC-G classified 17 patients in the >90 mL/min/1.73 m2 subgroup and 6 and 11 patients in the 60
to 90 and <60 mL/min/1.73 m2 subgroups, respectively. In multivariate analysis, patients with eGFRC-G < 60 mL/min/1.73 m2 had
19.5-fold (95% confidence interval [CI] 1.55-178) higher mortality risk and 5.48-fold (95% CI 1.75-24.21) higher major adverse
cardiac events risk compared to patients with eGFRC-G >90 mL/min/1.73 m2 (P ¼ .01 and P ¼ .01, respectively); the eGFRMDRD
was not predictive. Although the MDRD equation more accurately estimates GFR in certain populations, the CG formula may be
a better predictor of adverse events.
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