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Evaluation of the Effect of Topical Application of Nigella sativa on Acute Radiation-Induced Nasal Mucositis

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dc.contributor.authorŞENELDİR, HATİCE
dc.contributor.authorÇANAKCI, HASAN
dc.contributor.authorŞAHİN YILMAZ, ASLI AYŞE
dc.contributor.authorKİR, GÖZDE
dc.contributor.authorERİŞ, ALİ HİKMET
dc.contributor.authorMAYADAĞLI, ALPASLAN
dc.contributor.authorOYSU, ÇAĞATAY
dc.contributor.institutionauthorERİŞ, ALİ HİKMET
dc.contributor.institutionauthorMAYADAĞLI, ALPASLAN
dc.date.accessioned2019-10-05T15:06:02Z
dc.date.available2019-10-05T15:06:02Z
dc.date.issued2018-05-01
dc.description.abstractThe goal of this study was to demonstrate the effect of radiotherapy (RT) on nasal mucosa in rats and to evaluate the radioprotective effects of the topical application of black seed oil (Nigella sativa [NS]) to treat acute radiation-induced nasal mucositis.A total of 18 rats were randomized into 3 groups, with 6 animals per group. The rats in group 1 were topically administered saline in the nasal cavity after sham irradiation. Group 2 received saline at the same dose after irradiation. Group 3 was given NS after irradiation. The rats in groups 2 and 3 were irradiated with a single dose of 40 Gy to the nasal and paranasal area. Only one drop of saline (0.05 mL) was applied to each nostril in the first, second, and third days after RT in groups 1 and 2. One drop of cold press NS (0.05 mL) was applied to each nostril in group 3. Fourteen days after irradiation, the nasal mucosal tissues were excised for histopathological evaluation. Vascular dilatation, inflammatory cell infiltration, superficial erosion, and formation of exudates were classified according to the severity.No evidence of mucositis was observed in group 1. Of all the parameters the only statistically significant difference between groups 2 and 3 were observed for superficial erosion- (P<0.05). Overall microscopic observations in the NS-treated group were better than in group 2.The preliminary results of our study have shown that local application of NS to the nasal mucosa may be an effective treatment of acute nasal mucositis due to RT.
dc.identifier10.5606/kbbihtisas.2012.014
dc.identifier.citationÇANAKCI H., ŞAHİN YILMAZ A. A. , CANPOLAT M. S. , ŞENELDİR H., KİR G., ERİŞ A. H. , MAYADAĞLI A., OYSU Ç., -Evaluation of the Effect of Topical Application of Nigella sativa on Acute Radiation-Induced Nasal Mucositis-, JOURNAL OF CRANIOFACIAL SURGERY, cilt.29, ss.279-282, 2018
dc.identifier.doi10.1097/scs.0000000000004314
dc.identifier.pubmed29381633
dc.identifier.scopus85052915147
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5459
dc.identifier.wosWOS:000434303800025
dc.language.isoen
dc.titleEvaluation of the Effect of Topical Application of Nigella sativa on Acute Radiation-Induced Nasal Mucositis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameKulak burun boǧaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
local.avesis.id86832612-b591-48c7-94ea-8e7d3ba1d01e
local.avesis.response5329
local.publication.goal02 - Açlığa Son
local.publication.isinternational1
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relation.isGoalOfPublication.latestForDiscovery5246edf8-60d4-4a7b-9a27-c73e4a636141
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