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Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis

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dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorBATIREL, Ayse
dc.contributor.authorKarabay, Oguz
dc.contributor.authorAGALAR, Canan
dc.contributor.authorAkalin, Serife
dc.contributor.authorALICI, Ozlem
dc.contributor.authorAlp, Emine
dc.contributor.authorALTAY, Fatma Aybala
dc.contributor.authorALTIN, Nilgun
dc.contributor.authorArslan, Ferhat
dc.contributor.authorASLAN, Turan
dc.contributor.authorBekiroglu, Nural
dc.contributor.authorCESUR, Salih
dc.contributor.authorCelik, Aygul Dogan
dc.contributor.authorDogan, Mustafa
dc.contributor.authorDurdu, BÜLENT
dc.contributor.authorDuygu, Fazilet
dc.contributor.authorEngin, Aynur
dc.contributor.authorENGIN, Derya Ozturk
dc.contributor.authorGonen, Ibak
dc.contributor.authorGuciu, Ertugrul
dc.contributor.authorGUVEN, Tumer
dc.contributor.authorHATIPOGIU, Cigdem Ataman
dc.contributor.authorHosoglu, Salih
dc.contributor.authorKarahocagil, Mustafa Kasim
dc.contributor.authorKilic, Aysegul Ulu
dc.contributor.authorORMEN, Bahar
dc.contributor.authorOzdemir, Davut
dc.contributor.authorOZER, Serdar
dc.contributor.authorOZTOPRAK, Nefise
dc.contributor.authorSezak, Nurbanu
dc.contributor.authorTURHAN, Vedat
dc.contributor.authorTurker, Nesrin
dc.contributor.authorYilmaz, Hava
dc.contributor.institutionauthorDURDU, BÜLENT
dc.date.accessioned2019-10-05T14:38:58Z
dc.date.available2019-10-05T14:38:58Z
dc.date.issued2015-01-01
dc.description.abstractObjectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.
dc.identifier10.1097/scs.0000000000002589
dc.identifier.citationBalkan I. I. , BATIREL A., Karabay O., AGALAR C., Akalin S., ALICI O., Alp E., ALTAY F. A. , ALTIN N., Arslan F., et al., -Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis-, INDIAN JOURNAL OF PHARMACOLOGY, cilt.47, ss.95-100, 2015
dc.identifier.doi10.4103/0253-7613.150383
dc.identifier.pubmed25821319
dc.identifier.scopus84923055629
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4375
dc.identifier.wosWOS:000349144300018
dc.language.isoen
dc.titleComparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF CRANIOFACIAL SURGERY
local.avesis.id6abe6b06-5994-4c66-8145-45ccefe60ed7
local.avesis.response4245
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication9814f802-a79c-45fd-aa3e-f1ba9d40884b
relation.isAuthorOfPublication.latestForDiscovery9814f802-a79c-45fd-aa3e-f1ba9d40884b
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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