Publication:
Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

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dc.contributor.authorTuncay, Salih
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.authorSEÇEN, Hasan
dc.contributor.authorOcal, Nuket
dc.contributor.authorTopcu, GÜLAÇTI
dc.contributor.authorGuler, ERAY METİN
dc.contributor.institutionauthorŞENOL, HALIL
dc.contributor.institutionauthorGÜLER, ERAY METİN
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2019-10-05T14:43:38Z
dc.date.available2019-10-05T14:43:38Z
dc.date.issued2018-01-01
dc.description.abstractBackground: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.
dc.identifier10.14235/bs.2018.1147
dc.identifier.citationTuncay S., Senol H., Guler E. M. , Ocal N., SEÇEN H., Kocyigit A., Topcu G., -Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line-, MEDICINAL CHEMISTRY, cilt.14, ss.617-625, 2018
dc.identifier.pubmed29473521
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4585
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSynthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameBEZMIALEM SCIENCE
local.avesis.id70457d0a-4602-43d9-9fb2-48d905d2e2d3
local.avesis.response4455
local.indexed.atPubMed
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relation.isAuthorOfPublication68927a51-77a5-4d08-8370-23b470160061
relation.isAuthorOfPublication75babbd2-f46b-4121-aa00-54d883a6f907
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relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5

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