Publication:
Can serum histone H4 levels predict mucosal healing in Crohn-s disease?

dc.contributor.authorKÖKER, İBRAHİM HAKKI
dc.contributor.authorSÜMBÜL, BİLGE
dc.contributor.authorKİREMİTÇİ, SERCAN
dc.contributor.authorKOÇHAN, KORAY
dc.contributor.authorİNCE, ALİ TÜZÜN
dc.contributor.authorBİBERCİ KESKİN, Elmas
dc.contributor.authorŞENTÜRK, HAKAN
dc.contributor.institutionauthorKÖKER, İBRAHİM HAKKI
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.contributor.institutionauthorKİREMİTÇİ, SERCAN
dc.contributor.institutionauthorKOÇHAN, KORAY
dc.contributor.institutionauthorİNCE, ALİ TÜZÜN
dc.contributor.institutionauthorBİBERCİ KESKİN, ELMAS
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.date.accessioned2021-06-29T20:59:10Z
dc.date.available2021-06-29T20:59:10Z
dc.date.issued2021-01-01T00:00:00Z
dc.description.abstractIntroduction: Mucosal healing (MH) has been a treatment target with the introduction of biological agents in Crohn's disease (CD). Histone H4 increases in chronic inflammation. Aim: Our goal was to investigate the role of serum histone H4 in predicting MH. Material and methods: The study included 44 patients who applied to the endoscopy unit for ileocolonoscopic evaluation with the diagnosis of ileocecal CD and 26 healthy controls. After ileocolonoscopic evaluation, we divided the patients into 2 groups: those with and those without MH, according to the presence of endoscopic ulcer or erosion findings. Blood samples were taken from these patients to analyse serum histone H4 before the endoscopic procedure. We first compared serum histone H4 levels between CD patients and the healthy control group and then between those with and those without MH among the CD patients. Finally, we compared CRP, ESR, and serum histone H4 levels in patients with CD according to the presence of MH and symptoms. Results: Serum histone H4 levels were significantly higher in ileocolonic CD patients compared to the healthy control group (p = 0.002). Also, serum histone H4 levels were significantly higher in CD patients with no MH (p = 0.028) or symptomatic patients (p = 0.033). We did not find a significant difference in C-reactive protein and erythrocyte sedimentation rate levels between CD patients in the presence of MH (p = 0.281 and p = 0.203, respectively) or symptoms (0.779 and 0.652, respectively). Conclusions: Serum histone H4 might be a useful biomarker for MH prediction in ileocolonoscopic CD patients. Validation is needed for large numbers of patients.
dc.identifier.doi10.5114/pg.2021.106663
dc.identifier.pubmed34276839
dc.identifier.scopus85107977187
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29006
dc.identifier.wosWOS:000659394500008
dc.subjectCrohn’s disease
dc.subjecthistone H4
dc.subjectmucosal healing
dc.titleCan serum histone H4 levels predict mucosal healing in Crohn-s disease?
dc.typeArticle
dspace.entity.typePublication
local.avesis.id3bdbe672-63e5-4204-a7c2-7fd75711966c
local.publication.isinternational1
relation.isAuthorOfPublication34a32427-4642-4b2e-a79c-e01175ef38a9
relation.isAuthorOfPublication51568f47-69f1-46a2-b201-e6d6161080a8
relation.isAuthorOfPublication4145627c-024b-41dd-9df0-5e8924b91b3c
relation.isAuthorOfPublicationb76fc646-d4e6-42fc-86d4-534d33d0b6c9
relation.isAuthorOfPublication6daa6ab7-ee45-4f50-9e71-e831046b6462
relation.isAuthorOfPublication970f9eb4-1be0-4bd2-ba93-371a0049b85b
relation.isAuthorOfPublication278fcf63-3b92-4368-bff6-f140ebd9aeb3
relation.isAuthorOfPublication.latestForDiscovery278fcf63-3b92-4368-bff6-f140ebd9aeb3
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Can serum histone H4 levels predict mucosal healing in Crohn's disease.pdf
Size:
91.12 KB
Format:
Adobe Portable Document Format
Description: