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A multifunctional multimaterial system for on-demand protein release

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dc.contributor.authorTuncaboylu, DENİZ CEYLAN
dc.contributor.authorFRIESS, Fabian
dc.contributor.authorWISCHKE, Christian
dc.contributor.authorLENDLEIN, Andreas
dc.contributor.institutionauthorTUNCABOYLU, DENIZ CEYLAN
dc.date.accessioned2019-10-05T14:34:36Z
dc.date.available2019-10-05T14:34:36Z
dc.date.issued2018-08-28
dc.description.abstractIn order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation. Using devices from poly(epsilon-caprolactone) networks, it could be demonstrated that a shape-memory effect activated by heat or NIR light enabled on-demand tube shrinkage. The decrease of diameter of these shape-memory tubes (SMT) allowed expelling the payload as demonstrated for several proteins including SDF-1 alpha, a therapeutically relevant chemotactic protein, to achieve e.g. continuous release with a triggered add-on dosing (open tube) or an on-demand onset of bolus or sustained release (sealed tube). Considering the clinical relevance of protein factors in (stem) cell attraction to lesions and the progress in monitoring biomarkers in body fluids, such on-demand release systems may be further explored e.g. in heart, nerve, or bone regeneration in the future.
dc.identifier10.1016/j.poly.2011.02.044
dc.identifier.citationTuncaboylu D. C. , FRIESS F., WISCHKE C., LENDLEIN A., -A multifunctional multimaterial system for on-demand protein release-, JOURNAL OF CONTROLLED RELEASE, cilt.284, ss.240-247, 2018
dc.identifier.pubmed29913222
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4182
dc.language.isoen
dc.titleA multifunctional multimaterial system for on-demand protein release
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePOLYHEDRON
local.avesis.id65763899-cf6c-471a-a079-d16ac7994836
local.avesis.response4052
relation.isAuthorOfPublicationac53edd0-862b-4855-8c83-91c45c3cfd61
relation.isAuthorOfPublication.latestForDiscoveryac53edd0-862b-4855-8c83-91c45c3cfd61
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