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Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation

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dc.contributor.authorBAHADORİ, FATEMEH
dc.contributor.authorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.authorDAĞ, AYDAN
dc.contributor.authorTOPÇU, GÜLAÇTI
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.contributor.institutionauthorDAĞ, AYDAN
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2019-10-05T13:40:46Z
dc.date.available2019-10-05T13:40:46Z
dc.date.issued2017-11-01
dc.description.abstractSelf-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations of chemotherapeutics currently consist of SAS. According to our knowledge, a specific toxicity comparison based on material differences has not yet been performed. The purpose of this study was to evaluate and compare the toxicity of two SAS consisting of Sterically Stabilized Micelles (SSM) made of a lipid-based amphiphilic distearoyl-sn-glycero-phosphatidylethanolamine-polyethylene glycol (PEG)-2000 and a polymeric micelle (PM) consisting of Y-shape amphiphilic block copolymer, synthesized using poly ε-caprolactone and PEG. The mechanism of cytotoxicity and genotoxicity of micelles on L-929 healthy mouse fibroblast cells was assessed using Sulforhodamine-B, WST-1, Acridine Orange/Ethidium Bromide and alkaline single-cell gel electrophoresis assays. Results showed that SSM in conc. of 40 mg/mL shows very low cytotoxicity at the end of 24, 48 and 72 h. The DNA damage caused by SSM was much lower than PM while the latter one showed significant toxicity by causing apoptosis with the ED50 value of 3 mg/mL. While the DNA damage caused by SSM was ignorable, some DNA chain breaks were detected on cells treated with PM.en
dc.description.sponsorshipBezmiâlem Vakıf Üniversitesi
dc.identifier10.1016/j.phytol.2011.04.013
dc.identifier.citationBAHADORİ F., KOÇYİĞİT A., ONYUKSEL H., DAĞ A., TOPÇU G., -Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation-, TOXICS, cilt.6, ss.1-7, 2017
dc.identifier.pubmed29301191
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2707
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleCytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePHYTOCHEMISTRY LETTERS
local.avesis.id421dbde3-7537-4124-b18b-25367b803dbc
local.avesis.response2577
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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