Publication:
An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite.

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dc.contributor.authorKamil, Mohd
dc.contributor.authorAtmaca, Habibe N
dc.contributor.authorUnal, Sinem
dc.contributor.authorKina, Umit Y
dc.contributor.authorBurak, Pinar
dc.contributor.authorDeveci, Gozde
dc.contributor.authorYilmaz, Ilknur
dc.contributor.authorAly, Ahmed S I
dc.date.accessioned2023-05-16T14:57:39Z
dc.date.available2023-05-16T14:57:39Z
dc.date.issued2022-12-19T21:00:00Z
dc.description.abstractWe generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones. Autophagy-related genes were highly upregulated in SenCQ compared to ResCQ parasites during CQ treatment. This indicates that CQ resistance can be developed in the malaria parasite by the inhibition of autophagy as an alternative drug resistance mechanism.
dc.identifier.pubmed36342168
dc.identifier.urihttps://hdl.handle.net/20.500.12645/37889
dc.language.isoen
dc.subjectPlasmodium yoelii
dc.subjectautophagy
dc.subjectchloroquine
dc.subjectdrug resistance
dc.subjectdrug resistance mechanisms
dc.subjectmalaria
dc.titleAn Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite.
dspace.entity.typePublication
local.indexed.atPubMed

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