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Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis

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dc.contributor.authorKilic, Ulkan
dc.contributor.authorGok, Ozlem
dc.contributor.authorElibol-Can, BİRSEN
dc.contributor.authorUysal, Omer
dc.contributor.authorBacaksiz, AHMET
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.contributor.institutionauthorUYSAL, ÖMER
dc.contributor.institutionauthorBACAKSIZ, AHMET
dc.date.accessioned2019-10-05T13:08:06Z
dc.date.available2019-10-05T13:08:06Z
dc.date.issued2015-04-01
dc.description.abstractStatins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and are used to reduce the risk of coronary artery disease (CAD) due to their pleiotropic effects. Recently, greater focus has been placed on the role of sirtuin 1 (SIRT1) in cardiovascular disease research. However, insufficient data exist on the relationships between statins, SIRT1 protein levels, and SIRT1 gene variants. In the present study, we investigated the effects of statins, atorvastatin and rosuvastatin, in CAD patients by analysing the associations between SIRT1 gene variants, rs7069102C>G and rs2273773C>T, and SIRT1/endothelial nitric oxide (eNOS) expression, as well as total antioxidant and oxidant status, and the oxidative stress index. SIRT1 expression was significantly higher, and eNOS expression was significantly lower in CAD patients when compared with controls. Statin treatment reduced SIRT1 expression and increased eNOS expression, similar to the levels found in the control population, independent from the studied SIRT1 gene variants. Oxidative stress parameters were significantly increased in CAD patients, and were decreased by statin treatment, demonstrating the antioxidative effects of statins on atherosclerosis. These results indicate that statin treatment could produce its protective effect on cardiovascular disease through the inhibition of SIRT1 expression. This is the first study reporting on the effect of statins, specifically atorvastatin and rosuvastatin, on SIRT1 expression in CAD patients.
dc.identifier10.3906/biy-1902-77
dc.identifier.citationKilic U., Gok O., Elibol-Can B., Uysal O., Bacaksiz A., -Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis-, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.42, ss.321-330, 2015
dc.identifier.doi10.1111/1440-1681.12362
dc.identifier.scopus84925440227
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1399
dc.identifier.wosWOS:000351832200002
dc.language.isoen
dc.titleEfficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTURKISH JOURNAL OF BIOLOGY
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local.avesis.response1269
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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