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Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

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dc.contributor.authorGÜLÇİN, İlhami
dc.contributor.authorelias, Riad
dc.contributor.authorGepdiremen, ALİ AKÇAHAN
dc.contributor.authorChea, Aun
dc.contributor.authorTopal, Fevzi
dc.contributor.institutionauthorGEPDİREMEN, ALİ AKÇAHAN
dc.date.accessioned2020-10-29T14:38:58Z
dc.date.available2020-10-29T14:38:58Z
dc.date.issued2010-02-01T00:00:00Z
dc.description.abstractIn the present study, we determined the antioxidant activity of cepharanthine and fangchinoline from Stephania rotunda by performing different in vitro antioxidant assays, including 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, 2,2--azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD) radical scavenging, superoxide anion (O-2(center dot-)) radical scavenging, hydrogen peroxide scavenging, total antioxidant activity, reducing power, and ferrous ion (Fe2+) chelating activities. Cepharanthine and fangchinoline showed 94.6 and 93.3% inhibition on lipid peroxidation of linoleic acid emulsion at 30 mu g/mL concentration, respectively. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox indicated inhibitions of 83.3, 92.2, 72.4, and 81.3% on peroxidation of linoleic acid emulsion at the same concentration (30 mu g/mL), respectively. According to the results, cepharanthine and fangchinoline have effective antioxidant and radical scavenging activity.
dc.identifier.citationGÜLÇİN İ., elias R., Gepdiremen A. A. , Chea A., Topal F., -Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline-, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, ss.44-53, 2010
dc.identifier.doi10.3109/14756360902932792
dc.identifier.scopus74349130587
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25356
dc.identifier.wosWOS:000275000900006
dc.titleAntioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline
dc.typeArticle
dspace.entity.typePublication
local.avesis.id277bf541-c7e3-4499-a8a2-0f26c63a668a
local.publication.isinternational1
relation.isAuthorOfPublicationdc70adc1-eb72-4820-8b6d-4b39285a568f
relation.isAuthorOfPublication.latestForDiscoverydc70adc1-eb72-4820-8b6d-4b39285a568f
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