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Glycosylated hemoglobin A1c predicts coronary artery disease in non-diabetic patients

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dc.contributor.authorKayali, Yildiz
dc.contributor.authorÖZDER, ACLAN
dc.contributor.institutionauthorÖZDER, ACLAN
dc.date.accessioned2020-11-11T22:14:04Z
dc.date.available2020-11-11T22:14:04Z
dc.date.issued2020-10-01T00:00:00Z
dc.description.abstractBackground In primary care, there is a need for simple and cost-effective tool that will allow the determination of the risk of coronary artery disease (CAD). We aimed to research the value of glycosylated hemoglobin (HbA1c) in the prediction of coronary artery disease. Methods Patients admitted to the outpatient clinic of the Cardiology for angiography were retrospectively screened. Patients with diabetes or with HbA1c of 6.5 or above were excluded. Comparative HbA1c data were obtained according to the stenosis groups. Logistic regression analysis was used to investigate the risk factors affecting stenosis positivity. Results Of the study group, 120 patients were without any stenosis in any coronary artery, 56 patients were with >50% stenosis in one coronary artery, and 71 patients were with >50% stenosis in more than one coronary artery. There was a statistically significant difference between HbA1c measurements according to the degree of stenosis (P = .001 andP < .01, respectively). The odd ratio for HbA1c was 6.260 (95% CI: 3,160-12,401). According to the stenosis positivity, the cutoff point for HbA1c was found to be 5.6 and above. In the regression analysis, HbA1c was an independent risk factor for CAD. One unit increase in HbA1c level increases the risk of stenosis up to 12.4-fold (95% CI: 5,990-25,767). Conclusion The study showed HbA1c can be used as an independent marker in determining the probability and severity of coronary artery disease in non-diabetic individuals and as a useful marker in primary care predicting CAD.
dc.identifier.citationKayali Y., ÖZDER A., -Glycosylated hemoglobin A1c predicts coronary artery disease in non-diabetic patients-, JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2020
dc.identifier.doi10.1002/jcla.23612
dc.identifier.pubmed33034919
dc.identifier.scopus85092179640
dc.identifier.urihttp://hdl.handle.net/20.500.12645/27376
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jcla.23612
dc.identifier.wosWOS:000577488600001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcoronary artery disease
dc.subjecthemoglobin A1c
dc.subjectnon-diabetic
dc.subjectprediabetic
dc.subjectprimary care
dc.titleGlycosylated hemoglobin A1c predicts coronary artery disease in non-diabetic patients
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd62fdd4a-3e8c-447b-b25f-704d017e016d
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication20e51a9d-0cf9-4959-9ea0-0e2508af825d
relation.isAuthorOfPublication.latestForDiscovery20e51a9d-0cf9-4959-9ea0-0e2508af825d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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