Hidradenitis süpürativa: Epidemiyoloji, klinik özellikler ve komorbid ilişkiler / Hidradenitis suppurativa: Epidemiology, clinical features and comorbid relations

Abstract

Hidradenitis suppurativa is a long-term, recurrent disease affecting the apocrine gland-bearing skin area under the axilla, groin and breast. It is a chronic inflammatory disease with painful, deep-seated nodules and abscesses that may result in sinus tracts and scarring. Although it occurs frequently in 2-4 10 years, it is seen 3 times more in women than in men. Although the mechanism of HS has not been fully elucidated, lesion formation is believed to result from follicular hyperkeratosis and occlusion development within the pilosebaceous-apocrine unit. In addition to the central role of inflammatory cytokines, factors such as genetics, microorganisms and hormones have been shown to play a role in the pathogenesis of the disease. In this single-center study, we investigated the demographic and clinical features of HS and determined the risk factors for disease severity. We had the opportunity to work with 193 patients, including 72 female and 121 male patients in total. The mean age of the patients participating in the study was 34.51±12.11 years, and the mean disease duration was 5.94±6.65 years. The familial transmission rate in individuals with HS in our cohort was 21.8%. In the investigation of follicular occlusion tetrad, of which HS is an important part, 6.7% of the patients had dissecting cellulitis of the scalp, 10.9% had acne conglobata, and 35.8% had pilonidal sinus. In total, 5 patients have the all follicular occlusion tetrad is a symptom complex. 61.1% of the patients were Stage I, 24.4% were Stage II and 14.5% were Stage III. In the population included in the study, 93 patients (48.2%) were accompanied by at least one comorbidity, and psychiatric comorbidities were the most common, followed by diabetes mellitus and hypertension in the second and third place. When the relationships between the categorical variables and the gender variable were examined in the logistic regression analysis, the findings for BMI groups, alcohol use, work, acne vulgaris, dissecan cellulitis of scalp, acne conglobata, pilonidal disease and hurley variables were found viii to be statistically significant. More severe disease was associated with disease duration, number of cigarette packs/year, male gender, groin, hip, abdomen, head- neck, genital, and neck-back involvement. Our results of the study provide data on the demographic, clinical and comorbid characteristics of HS patients and contribute to the literature.