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Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

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dc.contributor.authorErtas, Abdulselam
dc.contributor.authorCakirca, Hatice
dc.contributor.authorYener, Ismail
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorFırat, Mehmet
dc.contributor.authorTOPÇU, GÜLAÇTI
dc.contributor.authorKOLAK, Ufuk
dc.contributor.institutionauthorTOPÇU, GÜLAÇTI
dc.date.accessioned2021-06-17T20:59:07Z
dc.date.available2021-06-17T20:59:07Z
dc.date.issued2021-11-01T00:00:00Z
dc.description.abstractIn the current study, the ethanol extracts prepared from the aerial parts and roots of an endemic species, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and tested for determination of their antioxidant activity using DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity (CUPRAC) test assays. Twenty known secondary metabolites were isolated from the active antioxidant fractions; rosmarinic acid (1), chlorogenic acid (2), caffeic acid (3), 4-hydroxybenzoic acid (4), benzoic acid (5), luteolin 7-O-glucoside (6), bis-(2-ethylhexyl)benzene-1,2-dicarboxylate (7), salvianolic acid A (8), salvianolic acid B (9), 7-acetylroyleanone (10), 6,7-dehydroroyleanone (11), ferruginol (12), inuroyleanol (13), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14), ursolic acid (15), oleanolic acid (16), taraxasterol (17), lupenone (18), beta-sitosterol (19), and stigmasterol (20). Rosmarinic acid, which was obtained from the aerial parts, was found to be the best antioxidant compound among the isolated secondary metabolites in DPPH free radical and ABTS cation radical scavenging, and CUPRAC assays (IC50: 1.20 +/- 0.04 mu g/mL, IC50: 1.74 +/- 0.06 mu g/mL, A(0.5): 1.22 +/- 0.02 mu g/mL, respectively). Chlorogenic and caffeic acids, luteolin 7-O-glucoside, salvianolic acids A and B, and inuroyleanol exhibited also high antioxidant activity in the mentioned assays.
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier.citationErtas A., Cakirca H., Yener I., Akdeniz M., Fırat M., TOPÇU G., KOLAK U., -Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa-, RECORDS OF NATURAL PRODUCTS, cilt.15, sa.6, ss.585-592, 2021
dc.identifier.doi10.25135/rnp.248.21.01.1933
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28989
dc.identifier.wosWOS:000658306500013
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleBioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa
dc.typeArticle
dspace.entity.typePublication
local.avesis.id9d22cb59-8c0c-4c81-9d35-3e0f0ebe8dbb
local.publication.isinternational1
relation.isAuthorOfPublication3c94748e-c303-4294-ad67-c5a0739628e5
relation.isAuthorOfPublication.latestForDiscovery3c94748e-c303-4294-ad67-c5a0739628e5
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