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Ozone (03)-oxygen mixture therapy inhibits endometrial implant growth

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dc.contributor.authorAktun, Lebriz Hale
dc.contributor.authorAcet, Mustafa
dc.contributor.authorATILGAN, REMZİ
dc.contributor.authorKaraca, Nilay
dc.contributor.authorYorgunlar, Betul
dc.contributor.authorCan, Behzat
dc.contributor.authorDAĞLI, ADİLE FERDA
dc.contributor.authorGul, Huseyin Fatih
dc.contributor.authorKumbak, Banu
dc.contributor.authorIrban, Arzu
dc.date.accessioned2020-10-21T20:17:01Z
dc.date.available2020-10-21T20:17:01Z
dc.date.issued2016-01-01T00:00:00Z
dc.description.abstractThe aim of this study was to investigate potential therapeutic efficiency of ozone therapy in the treatment of experimental endometriosis in rats. Fifteen rats were divided into three groups, which were labeled as the (1) sham control, (2) the ozone (treated with intraperitoneal ozone-oxygen mixture) and (3) the GnRH-agonist (given single dose (1 mg) leuprolide acetate depot formulation) group. Endometrial implant activity of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), and vasculary endothelial growth factor (VEGF) were measured after ozone-therapy. Furthermore, peritoneal fluid activity of SOD, MDA, and TNF-alpha were also measured before and after ozone-therapy. Serum AMH levels of the rats those were given ozone-therapy and control groups were measured. The rats given ozone-therapy showed significantly reduced endometriotic implant volumes. After ozone-therapy, a significant increase in activity of SOD in peritoneal fluid was detected. Conversely, implant levels of SOD in rats given ozone therapy was found to be significantly decreased. Both peritoneal fluid and implant levels of MDA were significantly decreased after ozone-therapy. Implant levels of TNF-alpha, IL-1 beta, and IL-6 were significantly increased following ozone-therapy. VEGF levels of implant was found to be unchanged after ozone-therapy. Serum AMH levels of animals were given ozone-therapy and control groups were similar. The number of both primordial and preantral follicles were significantly decreased after ozone-therapy. However, the number of atretic follicles were similar in ozone-therapy and control groups. Repeated administration of ozone-oxygen therapy in non-toxic doses inhibits growth of endometrial implants.
dc.identifier.citationAktun L. H. , Acet M., ATILGAN R., Karaca N., Yorgunlar B., Can B., DAĞLI A. F. , Gul H. F. , Kumbak B., Irban A., -Ozone (03)-oxygen mixture therapy inhibits endometrial implant growth-, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.9, ss.11590-11597, 2016
dc.identifier.scopus84976439480
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23380
dc.identifier.wosWOS:000379157300095
dc.titleOzone (03)-oxygen mixture therapy inhibits endometrial implant growth
dc.typeArticle
dspace.entity.typePublication
local.avesis.id0f720c22-155b-4143-8207-0db3ae2fdec8
local.publication.isinternational1
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