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Effects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats

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dc.contributor.authorGökalp Özkorkmaz, Ebru
dc.contributor.authorÖzay, Yusuf
dc.contributor.authorPehlivanoğlu, Burçin
dc.contributor.authorYıldız, Atilla
dc.contributor.authorGüzel, Sevda
dc.contributor.authorErdoğdu, İbrahim Halil
dc.contributor.authorDarcan, Sinan
dc.contributor.authorKUMAŞ, MELTEM
dc.date.accessioned2019-10-05T15:08:23Z
dc.date.available2019-10-05T15:08:23Z
dc.date.issued2019-03-01
dc.description.abstractThe genus Verbascum, commonly known as mullein, traditionally used in folk medicine, is known for its anti-inflammatory, antioxidant and antibacterial activities. Verbascum inulifolium Hub.-Mor. (Scrophulariaceae), is an endemic species from Turkey. Here, we examined the healing effect of methanol extract of the aerial parts of V. inulifolium on incisional and excisional skin wounds in diabetic and non-diabetic rats. Ointments of the extract were prepared in two concentrations (0.5 and 1% (w/w)) and applied topically on wound models once daily throughout for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatments, animals were sacrificed and measurements of hydroxyproline level and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, the granulation tissue thickness, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that the ethanolic extract of the aerial parts of V. inulifolium enhances the healing process of skin tissue in both non-diabetic and diabetic wounds. The best wound healing activity was observed in incisional wound treated with 0.5% (w/w) concentrated ointment (99.7%) and in excisional wound treated with 1% (w/w) concentrated ointment (98.1%) on day 14 according to macroscopic results.
dc.identifier
dc.identifier.citationÖzay Y., Güzel S., Gökalp Özkorkmaz E., Yıldız A., Yıldırım Z., Erdoğdu İ. H. , Darcan S., Pehlivanoğlu B., KUMAŞ M., -Effects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats-, INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, cilt.57, ss.157-167, 2019
dc.identifier.urihttps://hdl.handle.net/20.500.12645/5556
dc.titleEffects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameHepato-gastroenterology
local.avesis.id88b102bc-99be-4688-9ea4-6a2f42783de3
local.avesis.response5426
local.org.facultyTıp Fakültesi
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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