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The power of High Impact Amplitude Manipulation (HIAM) technique for extracting the basic spectra of two Fixed-dose combinations (FDC) -Spectrophotometric purity analysis via spectral contrast angle

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dc.contributor.authorSaleh, Sarah S.
dc.contributor.authorLotfy, Hayam M.
dc.contributor.authorTIRIS, GİZEM
dc.contributor.authorERK, NEVİN
dc.contributor.authorEl-Naem, Omnia A.
dc.contributor.institutionauthorTIRIS, GİZEM
dc.date.accessioned2022-05-05T20:59:18Z
dc.date.available2022-05-05T20:59:18Z
dc.date.issued2022-05-15T00:00:00Z
dc.description.abstract© 2022 Elsevier B.V.HIAM technique allows the extraction of the original constant signal of each single component out of interference signals of a mixture and further transformed into basic spectrum (D0). It includes the methods: ratio subtraction coupled with unified constant subtraction (RS-UCS), constant center (CC) and constant extraction (CE). The technique was introduced for the analysis of two pharmaceutical formulations used to treat cardiovascular diseases. The formulations are binary combinations of Amlodipine (AML) with either Atorvastatin (ATR) or Candesartan (CND) which shows interefernce absorbance signals. The technique was valid over the linearity range of (5.0–35.0 µg/ml) for AML, ATR and CND with recovery percentage 100.40 ± 1.88, 100.00 ± 0.86 and 99.83 ± 1.07, respectively. The extracted signals were tested for its purity by spectral contrast angle (cos θ) to illustrate the efficency of the HIAM technique where cos θ values ranges from (0.9902 to 0.9986). The presented technique was fully validated regarding ICH guidelines and were statistically compared using one-way ANOVA at 95% confidence.
dc.identifier.citationSaleh S. S. , Lotfy H. M. , TIRIS G., ERK N., El-Naem O. A. , -The power of High Impact Amplitude Manipulation (HIAM) technique for extracting the basic spectra of two Fixed-dose combinations (FDC) -Spectrophotometric purity analysis via spectral contrast angle-, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, cilt.273, 2022
dc.identifier.doi10.1016/j.saa.2022.121036
dc.identifier.pubmed35193003
dc.identifier.scopus85124796308
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30568
dc.titleThe power of High Impact Amplitude Manipulation (HIAM) technique for extracting the basic spectra of two Fixed-dose combinations (FDC) -Spectrophotometric purity analysis via spectral contrast angle
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaebb7a61-3e00-475d-9d9c-9cf63bb2a15b
local.publication.isinternational1
relation.isAuthorOfPublication1ab47475-d54a-4b46-a679-47fb775bc1ce
relation.isAuthorOfPublication.latestForDiscovery1ab47475-d54a-4b46-a679-47fb775bc1ce
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