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Effect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbits

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dc.contributor.authorKARAKAPLAN, MUSTAFA
dc.contributor.authorSahin, Nurhan
dc.contributor.authorMIREL, Efe
dc.contributor.authorErgen, Emre
dc.contributor.authorELMALI, Candan
dc.contributor.institutionauthorELMALI, NURZAT
dc.contributor.institutionauthorŞAHİN, NURHAN
dc.date.accessioned2019-10-05T14:38:01Z
dc.date.available2019-10-05T14:38:01Z
dc.date.issued2015-07-16
dc.description.abstractPurpose: The aim of the present study was to evaluate the effect of microfracture and intraarticular autologous conditioned plasma (ACP) injection on cartilage regeneration in a focal full-thickness chondral defect model created in the knee joint. Methods: Full-thickness chondral defects of 3 × 6 mm(2) were surgically created in right medial femoral condyles (MFC) of New Zealand rabbits, and the rabbits were then divided into three groups according to treatment: Group 1 received only microfracture (mfx), Group 2 received mfx plus intraarticular ACP, and Group 3 received mfx; the defect was covered by the periosteum, and then, ACP was applied subperiosteally and intraarticularly. Twelve weeks after injection, the animals were sacrificed and the femoral condyles were evaluated macroscopically and histologically by hematoxylin-eosin staining. Then, histological sections were scored using the International Cartilage Repair Society (ICRS) visual histological scale. Results: Findings showed that in both mfx/ACP-treated groups, the defects were filled regularly and smoothly, the defects had a greater fill and good integration into the surrounding host tissue, and the repair matrix had more hyaline-like character. On the other hand, defects were filled with an irregular, fibrous cartilage in the mfx-treated group. Histological scores in Group 2 and Group 3 were better compared to Group 1. Conclusion: In the present study, we were able to demonstrate a beneficial effect of intraarticular administration of ACP as a coadjuvant of microfractures in order to regenerate hyaline-like cartilage in full-thickness chondral lesions in a rabbit model.en
dc.identifier10.1179/027249303235002314
dc.identifier.citationKARAKAPLAN M., Elmali N., MIREL E., Sahin N., Ergen E., ELMALI C., -Effect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbits-, JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, cilt.10, 2015
dc.identifier.doi10.1186/s13018-015-0254-0
dc.identifier.pubmed26173978
dc.identifier.scopus85019202543
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4335
dc.identifier.wosWOS:000357919500001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleEffect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbits
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameANNALS OF TROPICAL PAEDIATRICS
local.avesis.id69b3d4ac-0251-405d-bb6e-25b5b3e05eb7
local.avesis.response4205
local.publication.isinternational1
relation.isAuthorOfPublicatione93337ae-6824-4aa2-82a0-cafa604ea70b
relation.isAuthorOfPublication84f8cc2e-0a04-41e1-b473-7f2af3f72119
relation.isAuthorOfPublication.latestForDiscovery84f8cc2e-0a04-41e1-b473-7f2af3f72119
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