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Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin

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dc.contributor.authorOzdemir, Mustafa
dc.contributor.authorYuksel, Mavise
dc.contributor.authorGÖKBEL, HAKKI
dc.contributor.authorOKUDAN, NİLSEL
dc.contributor.authorMevlitoglu, Inci
dc.date.accessioned2020-10-21T20:21:56Z
dc.date.available2020-10-21T20:21:56Z
dc.date.issued2012-05-01T00:00:00Z
dc.description.abstractCyclosporin has various effects on adipose tissue and glucose metabolism. This situation may lead to changes in serum levels of adipocyte-derived cytokines which have influence on the pathogenesis of psoriasis. The aim of this study was to evaluate the effect of cyclosporin treatment on some adipocyte-derived cytokines in psoriatic patients. This casecontrol study was performed between June 2009 and March 2010, at the Department of Dermatology of Meram School of Medicine. Serum leptin, adiponectin, resistin and ghrelin levels were assessed in 26 patients with psoriasis before and after cyclosporin treatment and body mass index-matched 26 healthy control subjects. The adipokines levels were compared between the groups. Serum leptin, ghrelin, resistin and adiponectin levels in patients with psoriasis before the treatment were higher than those of the control group but the differences were not statistically significant. A positive correlation between serum leptin and family history of psoriasis was detected (r = 0.398, P = 0.044). A strong negative correlation between the Psoriasis Area and Severity Index and serum ghrelin levels was seen (r = -0.52, P = 0.001) and there was a strong positive correlation between the Nail Psoriasis Severity Index and serum resistin levels (r = 0.62, P = 0.001). Following the treatment, a significant increase was seen in the serum level of adiponectin (P = 0.02) and resistin (P = 0.003). The correlations between the adipokines and the disease parameters before the treatment were lost after the treatment. Our results suggest that levels of some adipocyte-derived cytokines in psoriatic patients are affected by cyclosporin treatment.
dc.identifier.citationOzdemir M., Yuksel M., GÖKBEL H., OKUDAN N., Mevlitoglu I., -Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin-, JOURNAL OF DERMATOLOGY, cilt.39, ss.443-448, 2012
dc.identifier.doi10.1111/j.1346-8138.2011.01497.x
dc.identifier.pubmed22300284
dc.identifier.scopus84859800207
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23427
dc.identifier.wosWOS:000302722100005
dc.titleSerum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin
dc.typeArticle
dspace.entity.typePublication
local.avesis.id15251add-7363-4a37-9d6b-50a6ed818da6
local.publication.isinternational1
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