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Evaluation of Ki67 index in endoscopic ultrasound-guided fine needle aspiration samples for the assessment of malignancy risk in gastric gastrointestinal stromal tumors.

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dc.contributor.authorSenturk, Hakan
dc.contributor.authorSeven, GÜLSEREN
dc.contributor.authorKochan, KORAY
dc.contributor.authorCaglar, Erkan
dc.contributor.authorKiremitci, Sercan
dc.contributor.authorKoker, Ibrahim Hakki
dc.contributor.institutionauthorSEVEN, GÜLSEREN
dc.contributor.institutionauthorKOÇHAN, KORAY
dc.contributor.institutionauthorKÖKER, İBRAHİM HAKKI
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.date.accessioned2021-01-22T20:59:34Z
dc.date.available2021-01-22T20:59:34Z
dc.date.issued2020-10-05T00:00:00Z
dc.description.abstractBackground: The risk of malignancy in resected gastrointestinal stromal tumors (GISTs) depends on tumor size, location, and mitotic index. Reportedly, the Ki67 index has a prognostic value in resected GISTs. We aimed to analyze the accuracy of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) samples with reference to Ki67 index, using surgical specimens as the gold standard. Methods: Fifty-five patients who underwent EUS-FNA followed by surgical resection for gastric GISTs were retrospectively analyzed. Patients’ age and sex; tumors’ size and location; mitotic index, cell type, cellularity, pleomorphism, presence of ulceration, hemorrhage, necrosis, mucosal or serosal invasion, growth pattern, and Ki67 index based on pathology were investigated. Results: Location in fundus, ulceration, hemorrhage, mucosal invasion, and Ki67 index in surgical specimens were significant in predicting high-risk groups (P < 0.05) on univariate analysis. resence of bleeding (P = 0.034) and the Ki67 index (P = 0.018) were the only independent significant factors in multivariate analysis. The optimal cutoff level of Ki67 was 5%, with 88.2% sensitivity and 52.8% specificity (P = 0.021). The mean Ki67 index was lower in EUS-FNA samples than in surgical specimens [2% (1-15) vs. 10% (1-70), P = 0.001]. The rank correlation coefficient value of Ki67 was 0.199 (P = 0.362) between EUS-FNA and surgical samples and showed no reliability for EUS-FNA samples. Conclusion: The Ki67 index in resected specimens correlated with high-risk GISTs, although it had no additive value to the current criteria. The Ki67 index in EUS-guided FNA samples is not a reliable marker of proliferation in GISTs.en
dc.identifier.citationSeven G., Kochan K., Caglar E., Kiremitci S., Koker I. H. , Senturk H., -Evaluation of Ki67 index in endoscopic ultrasound-guided fine needle aspiration samples for the assessment of malignancy risk in gastric gastrointestinal stromal tumors.-, Digestive diseases (Basel, Switzerland), 2020
dc.identifier.doi10.1159/000511994
dc.identifier.pubmed33017820
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28139
dc.identifier.urihttps://www.karger.com/Article/Abstract/511994
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.holderDigestive Diseases
dc.subjectDigestive Diseases
dc.titleEvaluation of Ki67 index in endoscopic ultrasound-guided fine needle aspiration samples for the assessment of malignancy risk in gastric gastrointestinal stromal tumors.
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery278fcf63-3b92-4368-bff6-f140ebd9aeb3
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