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Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population

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dc.contributor.authorDilek, Ozturk
dc.contributor.authorEzgi, Oztas
dc.contributor.authorHalil, Kara
dc.contributor.authorCihan, Uras
dc.contributor.authorGul, Ozhan
dc.contributor.institutionauthorÖZTÜRK CİVELEK, DİLEK
dc.date.accessioned2020-01-13T20:59:34Z
dc.date.available2020-01-13T20:59:34Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractAim: Breast cancer is the most common cancer and the second leading cause of cancer-related deaths among women. Several genetic and environmental factors are known to be involved in breast cancer pathogenesis, but the exact etiology of this disease is complicated and not completely understood. We aimed to investigate whether the gene polymorphisms of ABCB1 and ABCG2 carrier proteins and COX2 enzyme affect breast cancer risk. Method: ABCG2 C421A (rs2231142), ABCB1 C3435T (rs1045642), COX-2 T8473C (rs5275) and COX-2 G306C (rs5277) were genotyped 104 breast cancer patients and 90 healthy controls using a real-time PCR for breast cancer susceptibility. Results: Patients carrying ABCG2 C421A, the CC genotype, had a higher risk of disease compared with patients carrying any A allele (OR = 3.06; 95% CI = 1.49–6.25, p = 0.0019). The other variants showed no association with breast cancer (p > 0.05). Comparing the pathological parameters with the variants, only, the frequency of C allele of ABCB1 C3435T was significantly lower in the estrogen receptor-a (ERa) (OR = 2.25; 95% CI: 0.75–6.76; p = 0.041) and progesterone receptor (PgR) (OR = 3.67; 95% CI: 1.34–10.03; p = 0.008) positive breast cancer patients. Conclusion: ABCB1 C3435T and ABCG2 C421A might represent a potential risk factor for breast cancer for Turkish womenen
dc.identifier.citationZeliha K. P. , Dilek O., Ezgi O., Halil K., Cihan U., Gul O., -Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population-, Saudi Pharmaceutical Journal, 2019
dc.identifier.doi10.1016/j.jsps.2019.11.024
dc.identifier.pubmed32042261
dc.identifier.scopus85077167341
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/12285
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleAssociation between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population
dc.typeArticle
dspace.entity.typePublication
local.avesis.idad609186-05f5-43f1-b094-adc78e40f421
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication821c461c-752b-4a78-a2e5-a6aaf5076b88
relation.isAuthorOfPublication.latestForDiscovery821c461c-752b-4a78-a2e5-a6aaf5076b88
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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