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The antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model

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dc.contributor.authorKilic, Elif
dc.contributor.authorTÜRKOĞLU, AHMET
dc.contributor.authorKeles, Aysenur
dc.contributor.authorEkinci, Aysun
dc.contributor.authorKesgin, Siddika
dc.contributor.authorGumus, Metehan
dc.date.accessioned2020-10-22T20:28:52Z
dc.date.available2020-10-22T20:28:52Z
dc.date.issued2016-01-01T00:00:00Z
dc.description.abstractObjectives: We investigated whether pomegranate extract plays a protective antioxidant role against mesenteric ischemia-reperfusion injury (IR), which can lead to a systemic response and damage distant organs, such as the lung, liver, and kidney. Methods: Forty female Wistar-Albino rats were separated into four groups: laparotomy, laparotomy + PG, mesenteric IR, and mesenteric IR and pomegranate (IR + PG). In the laparotomy + PG and IR + PG groups, pomegranate (225 mg/kg) was given by oral gavage at the beginning of the study. Ischemia was induced for 30 minutes, and reperfusion was subsequently allowed for 60 minutes in the IR and IR + PG groups. The malondialdehyde (MDA) and total antioxidant activity (AOA) levels were evaluated in blood samples. Additionally, all tissues were removed for the measurement of AOA and total oxidant status as well as for subsequent histopathological evaluation. The oxidative stress index was calculated. Results: Histopathological changes in all organs were significantly higher in the IR group and significantly lower in the IR + PG group vs. the other groups. Serum MDA levels were significantly lower in the IR + PG group than in the IR group. No significant difference was found in AOA levels of the groups. Discussion: These data may explain the positive protective effects of pomegranate based on the histopathologic findings in ischemic conditions in an intestinal IR injury model.
dc.identifier.citationKilic E., TÜRKOĞLU A., Keles A., Ekinci A., Kesgin S., Gumus M., -The antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model-, REDOX REPORT, cilt.21, ss.6-13, 2016
dc.identifier.doi10.1179/1351000215y.0000000013
dc.identifier.pubmed26010809
dc.identifier.scopus84978763884
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24820
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1179/1351000215Y.0000000013
dc.identifier.wosWOS:000373311900002
dc.subjectIntestinal ischemia
dc.subjectMalondialdehyde
dc.subjectPomegranate
dc.subjectReperfusion
dc.titleThe antioxidant effects of pomegranate extract on local and remote organs in a mesenteric ischemia and reperfusion model
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide8ebfa5b-aa60-41a1-8883-85b43b0058e3
local.publication.isinternational1
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