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New Fetal Dose Estimates from F-18-FDG Administered During Pregnancy: Standardization of Dose Calculations and Estimations with Voxel-Based Anthropomorphic Phantoms

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dc.contributor.authorZanotti-Fregonara, Paolo
dc.contributor.authorChastan, Mathieu
dc.contributor.authorEdet-Sanson, Agathe
dc.contributor.authorEkmekcioglu, Ozgul
dc.contributor.authorErdogan, EZGİ BAŞAK
dc.contributor.authorHapdey, Sebastien
dc.contributor.authorHindie, Elif
dc.contributor.authorStabin, Michael G.
dc.contributor.institutionauthorERDOĞAN, EZGİ BAŞAK
dc.date.accessioned2019-12-25T20:59:46Z
dc.date.available2019-12-25T20:59:46Z
dc.date.issued2016-11-01
dc.description.abstractData from the literature show that the fetal absorbed dose from 18F-FDG administration to the pregnant mother ranges from 0.5E-2 to 4E-2 mGy/MBq. These figures were, however, obtained using different quantification techniques and with basic geometric anthropomorphic phantoms. The aim of this study was to refine the fetal dose estimates of published as well as new cases using realistic voxel-based phantoms. Methods: The 18F-FDG doses to the fetus (n = 19; 5-34 wk of pregnancy) were calculated with new voxel-based anthropomorphic phantoms of the pregnant woman. The image-derived fetal time-integrated activity values were combined with those of the mothers' organs from the International Commission on Radiological Protection publication 106 and the dynamic bladder model with a 1-h bladder-voiding interval. The dose to the uterus was used as a proxy for early pregnancy (up to 10 wk). The time-integrated activities were entered into OLINDA/EXM 1.1 to derive the dose with the classic anthropomorphic phantoms of pregnant women, then into OLINDA/EXM 2.0 to assess the dose using new voxel-based phantoms. Results: The average fetal doses (mGy/MBq) with OLINDA/EXM 2.0 were 2.5E-02 in early pregnancy, 1.3E-02 in the late part of the first trimester, 8.5E-03 in the second trimester, and 5.1E-03 in the third trimester. The differences compared with the doses calculated with OLINDA/EXM 1.1 were +7%, +70%, +35%, and -8%, respectively. Conclusion: Except in late pregnancy, the doses estimated with realistic voxelwise anthropomorphic phantoms are higher than the doses derived from old geometric phantoms. The doses remain, however, well below the threshold for any deterministic effects. Thus, pregnancy is not an absolute contraindication of a clinically justified 18F-FDG PET scan.en
dc.identifier.citationZanotti-Fregonara P., Chastan M., Edet-Sanson A., Ekmekcioglu O., Erdogan E. B. , Hapdey S., Hindie E., Stabin M. G. , -New Fetal Dose Estimates from F-18-FDG Administered During Pregnancy: Standardization of Dose Calculations and Estimations with Voxel-Based Anthropomorphic Phantoms-, JOURNAL OF NUCLEAR MEDICINE, cilt.57, ss.1760-1763, 2016
dc.identifier.doi10.2967/jnumed.116.173294
dc.identifier.scopus84994797907
dc.identifier.urihttps://hdl.handle.net/20.500.12645/10884
dc.identifier.urihttp://jnm.snmjournals.org/content/57/11/1760.long
dc.identifier.wosWOS:000387097000023
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject18F-FDG
dc.subjectPET
dc.subjectDosimetry
dc.subjectPregnancy
dc.subjectRadiation safety
dc.subjectRadiobiology/dosimetry
dc.titleNew Fetal Dose Estimates from F-18-FDG Administered During Pregnancy: Standardization of Dose Calculations and Estimations with Voxel-Based Anthropomorphic Phantoms
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7426aa6f-19de-44f2-acf3-c7c4e167d4eb
local.publication.goal16 - Barış, Adalet ve Güçlü Kurumlar
local.publication.isinternational1
relation.isAuthorOfPublication98bbbec2-b351-430e-a436-008a1d0a32fd
relation.isAuthorOfPublication.latestForDiscovery98bbbec2-b351-430e-a436-008a1d0a32fd
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relation.isGoalOfPublication.latestForDiscovery7e7ce1dc-9556-4fa2-b604-c2ba181d38b9
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