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Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

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dc.contributor.authorKaraaslan, Elif
dc.contributor.authorKalkan-Yazıcı, Merve
dc.contributor.authorHasanoğlu, Sevde
dc.contributor.authorKarakeçili, Faruk
dc.contributor.authorÖzdarendeli, Aykut
dc.contributor.authorKalkan, Ahmet
dc.contributor.authorKılıç, Ali Osman
dc.contributor.authorDoymaz, Mehmet Ziya
dc.contributor.institutionauthorÇETİN, NESİBE SELMA
dc.contributor.institutionauthorDOYMAZ, MEHMET ZIYA
dc.date.accessioned2022-01-07T20:59:45Z
dc.date.available2022-01-07T20:59:45Z
dc.date.issued2021-12-01T00:00:00Z
dc.description.abstractIn 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather scarce. Due to its indispensable roles in the viral life cycle, NP becomes a logical target for detailed viral immunology studies. In this study, humoral immunity to NP was investigated in CCHF survivors, as well as in immunized mice and rabbits. Abundant antibody response against NP was demonstrated both during natural infection in humans and following experimental immunizations in mice and rabbits. Also, cellular immune responses to recombinant NP (rNP) was detected in multispecies. This study represents the most comprehensive investigation on NP as an inducer of both humoral and cellular immunity in multiple hosts and proves that rNP is an excellent candidate warranting further immunological studies specifically on vaccine investigations.
dc.identifier.doi10.1371/journal.pntd.0009973
dc.identifier.pubmed34851958
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30030
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCrimean-Congo Hemorrhagic Fever Virus (CCHFV)
dc.subjectNucleocapsid Protein (NP)
dc.titleImmune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4d892cc9-b9c8-40fb-ac5a-1d8b20d1b8ad
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c

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